Results 1 to 11 of 11

Thread: IGF and localized muscle growth studies

  1. #1
    MuscleChemistry Guru Spiderman's Avatar
    Join Date
    Oct 2002
    Location
    Oklahoma for now
    Age
    34
    Posts
    1,854
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    37728

    Default IGF and localized muscle growth studies



    IGF-1 Sale!
    These are definitely not conclusive as they were not done on humans, but they do give a lot of credibility to the notion that IGF does give localized growth. Here they are:

    http://jap.physiology.org/cgi/conten...ract/84/5/1716

    http://www.iovs.org/cgi/content/abstract/47/6/2461

    Enjoy
    "We're only gettin started"

    "All information given by Spiderman is for entertainment purposes only"

  2. #2
    MuscleChemistry Newbie
    Join Date
    Aug 2007
    Location
    Close to the Ocean
    Age
    60
    Posts
    13
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    0

    Cool

    Aloha Spiderman,

    Very interesting articles. The study below used direct IM to attain the results listed, therefore what would be the benefit of us doing of igf?
    How would the daily dose used in this study correlate to a adult male?

    EOMs demonstrate significant numbers of cells expressing the IGF receptor. After the EOMs were injected with IGF-I, there were significant increases both in muscle force generation and cross-sectional area at all doses tested in this study. Doses of 10 and 25 g IGF-I were most effective.

    CONCLUSIONS. Direct muscular injection of IGF-I effectively increases EOM force generation without the potential biomechanical hazards of surgery such as permanently altered muscle length or insertional position on the globe.


    Mahalo nui loa,
    Viking

  3. #3
    MuscleChemistry Guru Spiderman's Avatar
    Join Date
    Oct 2002
    Location
    Oklahoma for now
    Age
    34
    Posts
    1,854
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    37728

    Default

    Quote Originally Posted by Viking1

    The study below used direct IM to attain the results listed, therefore what would be the benefit of us doing of igf?
    How would the daily dose used in this study correlate to a adult male?

    EOMs demonstrate significant numbers of cells expressing the IGF receptor. After the EOMs were injected with IGF-I, there were significant increases both in muscle force generation and cross-sectional area at all doses tested in this study. Doses of 10 and 25 g IGF-I were most effective.

    CONCLUSIONS. Direct muscular injection of IGF-I effectively increases EOM force generation without the potential biomechanical hazards of surgery such as permanently altered muscle length or insertional position on the globe.


    Mahalo nui loa,
    Viking

    Q1 --> This would all depend on how you apply your IGF. While I do not advocate the IM use of IGF this was the way the study was set up and there were definite benefits to it. The study was done using the Superior Rectus muscle of the eye and (EOM) which increased the amount of force generated in the muscle treated with IGF vs. the contralateral EOM. It also increased the cross-sectional area of the treated muscle which indicates not only a localized increase in muscle force, but a localized increase in muscle size (i.e. muscle cross-sectional area) vs. the contralateral EOM.

    Q2 --> I don't know exactly how the dose used would correlate to an adult male. I'm not trying to find the best dose of IGF to use to get great results...that would needs it's own study using an average adult male and may other factors, which I don't see being done any time soon...just trying to show that with IM treatment of IGF there are site specific effects.
    "We're only gettin started"

    "All information given by Spiderman is for entertainment purposes only"

  4. #4
    MuscleChemistry Junior Member
    Join Date
    Sep 2007
    Posts
    238
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    255

    Default

    Interesting, but do these studies apply to the lr3 version as well? I was under the impression thru Marble and others that lr3 did not have the localized affect of regular IGF-1.

  5. #5
    MuscleChemistry Guru Spiderman's Avatar
    Join Date
    Oct 2002
    Location
    Oklahoma for now
    Age
    34
    Posts
    1,854
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    37728

    Default

    I believe lr3 does have the localized effect...the difference between IGF-lr3 and IGF-1 is that IGF-1 is taken up very quickly by IGFBPs (IGF binding proteins). The common theory is that IGF-1 binds only to the muscle cells @ the site injected and not anywhere else, but this is not true. It binds to the site (giving site specific effects) and the rest of it gets taken up by the IGFBPs. With IGF-lr3 you have the same binding effects @ the site, but the lr3 version is not taken up by any IGFBPs. This means if you inject to much of it (an amount that can't be taken up by the muscle cells) it will make it's way out into the body, specifically in the intestines. There are more receptors for IGF here than anywhere else in your body which is what gives the gut growth @ higher doses.

    While it is true that IGF-lr3 does have a longer half life than IGF-1 this does not mean that it doesn't have the same site specific effects. When either IGF-lr3 or IGF-1 bind to muscle cell receptors a cellular response is initiated that takes about 72 hours to complete and THIS is what we are interested in.
    "We're only gettin started"

    "All information given by Spiderman is for entertainment purposes only"

  6. #6
    MuscleChemistry Junior Member
    Join Date
    Sep 2007
    Posts
    238
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    255

    Default

    Thanks for the response. With that logic in mind, do you believe that ED dosing of the average 40-80 mcgs is not a good idea for those that want to avoid negative feedback, as well as the potential for spillover into the intestinal tract? I've read about EOD and 3x weekly dosing, but would like some opinions as to weather these protocols are effective, or simply a waste of time. In other words, are gains dependent on maintaining a steady elevated level of lr3 (as with AAS) via daily dosing; thus, making negative feedback and spillover a necessary evil during lr3 experimentation? All responses appreciated.

  7. #7
    MuscleChemistry Guru Spiderman's Avatar
    Join Date
    Oct 2002
    Location
    Oklahoma for now
    Age
    34
    Posts
    1,854
    Credits
    0
    Thanks (Given)
    0
    Thanks (Received)
    0
    Likes (Given)
    0
    Likes (Received)
    0
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    37728

    Default

    I personally am going to run it both EOD and 3x weekly within the next 12 weeks to see which works better for me, but yes I believe these two options offer a better way to avoid negative feedback (theoretically) as I haven't tested any of this out on myself yet...just been reading a lot on to to make sure I do it right. I also believe that you don't need to keep steady blood levels of IGF-lr3 because any IGF in your blood levels means it did not get taken up by the muscle cells and it will end up going elsewhere in your body (could be good if it goes to other muscle cells, but it is very likely that some will go to you intestines) However, that is not to say that taking 40-80 mcgs/day will give you negative feedback as every person is different, you need to experiment and see what works for you personally, but it's best to experiment after you have the knowledge to understand what is going on inside your body, which it looks like you have.
    "We're only gettin started"

    "All information given by Spiderman is for entertainment purposes only"

  8. #8
    Presser Presser's Avatar
    Join Date
    May 2002
    Posts
    19,062
    Credits
    57,326
    Thanks (Given)
    257
    Thanks (Received)
    151
    Likes (Given)
    6883
    Likes (Received)
    4492
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    10

    Default

    bump


  9. #9
    MuscleChemistry Guru
    Join Date
    Feb 2002
    Age
    43
    Posts
    6,070
    Credits
    62
    Thanks (Given)
    2
    Thanks (Received)
    1
    Likes (Given)
    39
    Likes (Received)
    27
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    6371

    Default

    i have found that post workout worked well for muscle growth and everyday worked well for both growth and fat loss
    The will to win is not nearly as important as the will to prepare to win.
    The tragedy of life doesn't lie in not reaching your goals. The tragedy lies in not having any goals to reach.

  10. #10
    Presser Presser's Avatar
    Join Date
    May 2002
    Posts
    19,062
    Credits
    57,326
    Thanks (Given)
    257
    Thanks (Received)
    151
    Likes (Given)
    6883
    Likes (Received)
    4492
    Dislikes (Given)
    0
    Dislikes (Received)
    0
    Rep Power
    10

    Default

    bump


  11. #11
    saudades
    MC Guest

    Default



    I can attest to the fact that it does indeed give you localized muscle growth. If you look at my pics in the Members section, you can see how it helped my quads and arms when I applied it to them.

Similar Threads

  1. Best IGF read (takes about 30 min)
    By NAIR in forum MuscleChemistry Discussion
    Replies: 8
    Last Post: 07-18-2007, 02:08 PM
  2. Question About Satellite Cells & MGF
    By BIGnSlim in forum Peptides Questions & Answers.
    Replies: 10
    Last Post: 07-12-2007, 12:15 AM
  3. Insulin & HGH
    By giantkilr in forum MuscleChemistry Discussion
    Replies: 3
    Last Post: 12-12-2006, 10:38 AM

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •