drtbear1967
Musclechemistry Board Certified Member
Is trestolone the new testosterone? Trestolone was first synthesized as a male birth control option, when researchers were looking for a safer alternative to test. Test converts to DHT, which can have deleterious effects on your prostate in the long term. Trestolone, due to its alpha-methyl group on carbon 7, cannot convert to DHT via 5a-reductase. This methyl group also prevents it from binding to sex hormone binding globulin, the protein that renders test/estrogen inactive. This means sex drive is very high while on cycle, something 19-nortestosterone derivatives are not known for.
In a study in healthy males comparing trestolone to test, all health biomarkers including HDL/LDL, PSA, total triglycerides, and hematocrit levels all were less affected than testosterone. Being a male contraceptive candidate, trestolone significantly lowered both LH and FSH, 90% and 91%, respectively in 4 weeks. Levels returned to baseline post cycle. The other major side effect is trestolone can readily convert to a strong estrogen, 7a-methyl-estradiol which also cannot bind to SHBG. An aromatase inhibitor is strongly recommended. IMO, trestolone is significantly more anabolic than testosterone, mg for mg. Suggested doses in literature are in the 300-400mg/week
In a study in healthy males comparing trestolone to test, all health biomarkers including HDL/LDL, PSA, total triglycerides, and hematocrit levels all were less affected than testosterone. Being a male contraceptive candidate, trestolone significantly lowered both LH and FSH, 90% and 91%, respectively in 4 weeks. Levels returned to baseline post cycle. The other major side effect is trestolone can readily convert to a strong estrogen, 7a-methyl-estradiol which also cannot bind to SHBG. An aromatase inhibitor is strongly recommended. IMO, trestolone is significantly more anabolic than testosterone, mg for mg. Suggested doses in literature are in the 300-400mg/week
