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Trivial really, just an issue of which colored box I deleted during splicing. Inane detail aside, does this make it clear why you inject FS344 *DNA* but should use FS 315 *peptide*?

By the way, did that in PowerPoint. Anyone is welcome to the orginal file, if I knew how to post it. If there is anything you need clarified, it's pretty easy to edit. There is one tiny scientific error, but that's hardly the point of the South Park version, so I'll just leave it. Extra credit...

Follistatin transcription, translation, and secretion Hope you guys had a great holiday. Finally got this done. Take home point: FS344 is never found in the bloodstream. After it pays the toll to go from the cell to the bloodstream, it is FS315.

It is NOT easy to visualize what's going on when you have stuff happening inside the cell, outside the cell (blood stream), versions including FS344, FS315, FS317, FS288, plus N-terminal & C-terminal... I had to go back and look it up to make sure I was describing it properly. Maybe I should...

I've got a theory (and that's all it is - not enough people reporting exactly what they used, where they got it, and what their results were), and I hope by posting this people in the market for Follistatin will start asking some questions and thereby get the manufacturers to create better...

Link policy No problem. I'll paste abstracts in in the future, although it sort of sucks that you can't use links to a government site like PubMed to refer people to authoritative information.

Some time ago I posted about clinical versus lab grade chemicals <O:p</O:pSince then, I've done a lot more Follistatin research and wanted to summarize one particular aspect of it for everyone. Specifically, what are the manufacturing differences possible with Follistatin and why should you...

Here are some other refs: Thymosin Beta-4 tumor - Google Scholar I have not read them all, but skimming some suggests that it can promote or decrease tumor growth (this isn't uncommon -- no one still agrees on whether testosterone promotes or abates prostate cancer, and perhaps it is...

See: TB500 Sounds like the real name is Thymosin Beta-4. It's easy to find info on it when you use the real name.

After the experience The Dude had (SERIOUS side effects from injecting something that was impure), I wanted to write a short piece on the importance of only using clinical grade substances in your supplement program. All substances, even with similar names, are not created equally. There are...

I'd like to add something from a scientific perspective about Precision Peptides: They are selling crap that, pure or not, they shouldn't even be selling. My guess is they just look for the cheapest possible supplier (china?) and resell whatever version that can of something, knowing that most...

Nobody else testing this? I know $600 isn't trivial, but I suspect there are plenty of people here spending more than that on other items. Be great to have feedback from multiple people to see how saudades experience compares.

Well, still can't find myostatin half life in the blood, but follistatin (see "Release of Activin and Follistatin during Cardiovascular Procedures Is Largely due to Heparin Administration," Phillips et al, 2000) and myostatin propeptide both seem to be around 2 hours. Sooo... If myostatin is...

Thanks again. As I elaborate on in another thread, given the results in human females, I would be pretty confident that doses in the 100-300mg range have an effect (I suspect that the mice doses are overkill and you shouldn't try for 4 grams even if you could afford it). How much less could...

Thanks for the info. Didn't realize it was based on economics lol. There is a study with post menopausal women that were given 0.1mg - 3mg/kg, with a 5% effect on weight at the 1 md/kg level after about a month (I think biweekly dosing). So, the mice levels definitely are not necessary. That...

If your body started making these antibodies, you would have an autoimmune disorder since you would be making antibodies to self (myostatin) proteins. Maybe desirable in this case, but scary in general -- autoimmune diseases can kill you. I strongly doubt it would happen.

I'm not seeing anyone mention how they are arriving at the conclusion that mcg doses are appropriate. At the risk of repeating what I pointed out in another thread, mouse studies are being done at 10mg/kg, up to even 50mg/kg. This is GRAMS of acvr2b for a human, and people here are talking...

Can you provide a reference for hyperplasia? Everything I've seen says hypertrophy alone accounts for the growth. The practical rammifications are unlcear regardless, but I would expect loss of mass after discontinuing.

Suadades, could you provide references and calculations for your acvr2b dosage decision? The studies I have seen on mice discuss 10mg+/kg, equating to nearly a gram (or more) per dose for a 75+ kg human. Obviously that is cost prohibitive. I have suspicisions that your dose is very reasonable...