[FONT=Times New Roman, serif]CJC-1295 The Simple Version
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[FONT=Times New Roman, serif]What is CJC-1295?[/FONT]
[FONT=Times New Roman, serif]CJC-1295 is the evolution of Growth-Hormone-Releasing-Hormone (GHRH). It is an analog of GHRH with 29 amino acids instead of 44. [/FONT]
[FONT=Times New Roman, serif]How does CJC-12965 work?[/FONT]
[FONT=Times New Roman, serif]CJC-1295 causes an increased amount of Growth Hormone (GH) to be released naturally by the body. This in turn may lead to increased protein synthesis, increased muscle mass, and increased physical strength. CJC-1295 may also aid in skin aging and wrinkle reduction. CJC-1295 is preferable to synthetic GH because it takes advantage of the body’s own pulsatile release mechanism. This causes zero negative feedback, unlike synthetic GH which causes desensitization over time. This means your body actually rejects the synthetic GH.[/FONT]
[FONT=Times New Roman, serif]Benefits and Potential of CJC-1295[/FONT]
[FONT=Times New Roman, serif]The benefits of CJC-1295 are those associated with increased levels of growth hormone. CJC-1295 DAC represents the best GHRH available today. In a pulsatility study performed on normal non-GH deficient people reported plasma levels were between 1 and 2 ng/ml one week after injection. The control, male and female, reported both accelerated and increased overall growth verses the non-CJC-1295 dosed controls. This supports the conclusion that CJC-1295 is substantially less risky for treatment of non-diseased subject, and substantially more beneficial therapy for subjects with pituitary diesase, than conential (synthetic) GH treatment [1]. [/FONT]
[FONT=Times New Roman, serif]Citations:[/FONT]
[FONT=Times New Roman, serif]1. Neuronal M3 Muscarinic Acetylcholine Receptors are Essential for Somatotroph Proliferation and Normal Somatic Growth. Dinesh Gautum. PNAS. April 14, 2009. Vol. 106 #15[/FONT]
[FONT=Times New Roman, serif]Now here is a more scientific version...this is written not at a doctorate level, just a more technical level, very readable still...I wrote this as a summation of the countless articles i have read. PLEASE NOTE THE RECOMMENDED DOSAGE WITH DAC...MANY GUYS ARE USING THIS ALL WRONG[/FONT]
[FONT=Times New Roman, serif]Basically CJC-1295 is a long acting growth hormone releasing hormone (GHRH) analog. GHRH, also known as growth hormone releasing factor or somatocrinin, is 44-amino acid peptide hormone which is produced by the arcuate nucleus in the hypothalamus. It stimulates secretion of growth hormone from the pituitary gland and is released in a pulsatile manner to ultimately stimulate pulsatile release of growth hormone. This pulsatile release in various peptides is the root cause for half life of the peptide due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV). Thus the need for increasing the life and bioavailability of peptide compelled pharmaceutical companies to come up with technologies like PEGylation to make peptides even more effective. [/FONT]
[FONT=Times New Roman, serif]Thus CJC-1295 which is a synthetic modification of GHRH with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively, is applied with Drug Affinity Complex (DAC) technology to its GHRH to increase its half-life. CJC-1295 DAC peptide carefully and covalently combines to circulate albumin after subcutaneous (SC) administration leading to lengthen its half life from seven minutes to more than seven days. With the help of highly effective bioconjugation process, hardly I % of CJC-1295 remain unreacted in vivo and CJC-1295 molecule attach itself to albumin easily for prolong half-life. There are several benefits that can be assured with CJC-1295 DAC after conducting its effective test on mice in clinical lab.[/FONT]
[FONT=Times New Roman, serif]
[/FONT]
[FONT=Times New Roman, serif]Its main function is to increase protein synthesis and stimulate new muscle tissue growth. It effectively curbs growth hormone (GH) deficiency in children to let them grow normally. CJC-1295 DAC leads to an increase in muscle mass and also adds to physical strength. [/FONT]
[FONT=Times New Roman, serif]It is also helpful in controlling skin aging and effective in reducing wrinkles. CJC-1295 DAC leads to re-growth of internal organs atrophied with age and result in hyperplasia to increase the number of muscle cells. Besides there are other benefits like increased bone density, strong immunity, faster recovery from injuries and lipolysis promotion to reduce body fat.
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[FONT=Times New Roman, serif]
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[FONT=Times New Roman, serif]As per dose recommendation, it is tested that a dose of 30 or 60 µg/kg is ideal to increase GH and insulin like growth factor (IGF-1) in healthy adults. Also due to long half-life and stability, taking CJC-1295 DAC 1-2 times per week would do the required job.[/FONT]
[FONT=Times New Roman, serif]1. To do the dosage calculations, simply take you weight in lbs and divide by 2.201. That equals your weight in KG.
[/FONT]
[FONT=Times New Roman, serif]2. Next multiply you weight in KG by any number from 30-60....most guys should start at 40 and move up to 60. This number, KG x 40 = the # of micrograms you are to take every 4 days.[/FONT]
[FONT=Times New Roman, serif]So lets uae me for instance, 190lbs/2.201 = approx 86kg. 86kg x 40 = 3440 micrograms or 3.44 milligrams...this is the dose every 4 days.[/FONT]
[FONT=Times New Roman, serif]Open the flood gates for questions...i'll be around working on Apollo Peptides and Prescription Nutrition all night[/FONT]
[FONT=Times New Roman, serif]
[/FONT]
[/FONT]
[FONT=Times New Roman, serif]What is CJC-1295?[/FONT]
[FONT=Times New Roman, serif]CJC-1295 is the evolution of Growth-Hormone-Releasing-Hormone (GHRH). It is an analog of GHRH with 29 amino acids instead of 44. [/FONT]
[FONT=Times New Roman, serif]How does CJC-12965 work?[/FONT]
[FONT=Times New Roman, serif]CJC-1295 causes an increased amount of Growth Hormone (GH) to be released naturally by the body. This in turn may lead to increased protein synthesis, increased muscle mass, and increased physical strength. CJC-1295 may also aid in skin aging and wrinkle reduction. CJC-1295 is preferable to synthetic GH because it takes advantage of the body’s own pulsatile release mechanism. This causes zero negative feedback, unlike synthetic GH which causes desensitization over time. This means your body actually rejects the synthetic GH.[/FONT]
[FONT=Times New Roman, serif]Benefits and Potential of CJC-1295[/FONT]
[FONT=Times New Roman, serif]The benefits of CJC-1295 are those associated with increased levels of growth hormone. CJC-1295 DAC represents the best GHRH available today. In a pulsatility study performed on normal non-GH deficient people reported plasma levels were between 1 and 2 ng/ml one week after injection. The control, male and female, reported both accelerated and increased overall growth verses the non-CJC-1295 dosed controls. This supports the conclusion that CJC-1295 is substantially less risky for treatment of non-diseased subject, and substantially more beneficial therapy for subjects with pituitary diesase, than conential (synthetic) GH treatment [1]. [/FONT]
[FONT=Times New Roman, serif]Citations:[/FONT]
[FONT=Times New Roman, serif]1. Neuronal M3 Muscarinic Acetylcholine Receptors are Essential for Somatotroph Proliferation and Normal Somatic Growth. Dinesh Gautum. PNAS. April 14, 2009. Vol. 106 #15[/FONT]
[FONT=Times New Roman, serif]Now here is a more scientific version...this is written not at a doctorate level, just a more technical level, very readable still...I wrote this as a summation of the countless articles i have read. PLEASE NOTE THE RECOMMENDED DOSAGE WITH DAC...MANY GUYS ARE USING THIS ALL WRONG[/FONT]
[FONT=Times New Roman, serif]Basically CJC-1295 is a long acting growth hormone releasing hormone (GHRH) analog. GHRH, also known as growth hormone releasing factor or somatocrinin, is 44-amino acid peptide hormone which is produced by the arcuate nucleus in the hypothalamus. It stimulates secretion of growth hormone from the pituitary gland and is released in a pulsatile manner to ultimately stimulate pulsatile release of growth hormone. This pulsatile release in various peptides is the root cause for half life of the peptide due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV). Thus the need for increasing the life and bioavailability of peptide compelled pharmaceutical companies to come up with technologies like PEGylation to make peptides even more effective. [/FONT]
[FONT=Times New Roman, serif]Thus CJC-1295 which is a synthetic modification of GHRH with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively, is applied with Drug Affinity Complex (DAC) technology to its GHRH to increase its half-life. CJC-1295 DAC peptide carefully and covalently combines to circulate albumin after subcutaneous (SC) administration leading to lengthen its half life from seven minutes to more than seven days. With the help of highly effective bioconjugation process, hardly I % of CJC-1295 remain unreacted in vivo and CJC-1295 molecule attach itself to albumin easily for prolong half-life. There are several benefits that can be assured with CJC-1295 DAC after conducting its effective test on mice in clinical lab.[/FONT]
[FONT=Times New Roman, serif]
[/FONT]
[FONT=Times New Roman, serif]Its main function is to increase protein synthesis and stimulate new muscle tissue growth. It effectively curbs growth hormone (GH) deficiency in children to let them grow normally. CJC-1295 DAC leads to an increase in muscle mass and also adds to physical strength. [/FONT]
[FONT=Times New Roman, serif]It is also helpful in controlling skin aging and effective in reducing wrinkles. CJC-1295 DAC leads to re-growth of internal organs atrophied with age and result in hyperplasia to increase the number of muscle cells. Besides there are other benefits like increased bone density, strong immunity, faster recovery from injuries and lipolysis promotion to reduce body fat.
[/FONT]
[FONT=Times New Roman, serif]
[/FONT]
[FONT=Times New Roman, serif]As per dose recommendation, it is tested that a dose of 30 or 60 µg/kg is ideal to increase GH and insulin like growth factor (IGF-1) in healthy adults. Also due to long half-life and stability, taking CJC-1295 DAC 1-2 times per week would do the required job.[/FONT]
[FONT=Times New Roman, serif]1. To do the dosage calculations, simply take you weight in lbs and divide by 2.201. That equals your weight in KG.
[/FONT]
[FONT=Times New Roman, serif]2. Next multiply you weight in KG by any number from 30-60....most guys should start at 40 and move up to 60. This number, KG x 40 = the # of micrograms you are to take every 4 days.[/FONT]
[FONT=Times New Roman, serif]So lets uae me for instance, 190lbs/2.201 = approx 86kg. 86kg x 40 = 3440 micrograms or 3.44 milligrams...this is the dose every 4 days.[/FONT]
[FONT=Times New Roman, serif]Open the flood gates for questions...i'll be around working on Apollo Peptides and Prescription Nutrition all night[/FONT]
[FONT=Times New Roman, serif]
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