1. Retatrutide
What it is:
A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors.
How it works:
GLP-1 reduces appetite and slows gastric emptying
GIP improves insulin sensitivity and nutrient partitioning
Glucagon increases energy expenditure and fat oxidation
Why it matters:
By suppressing intake and increasing metabolic output, Retatrutide produces some of the most dramatic weight-loss results seen in clinical trials, approaching 24% total bodyweight reduction.
2. SLU-PP-332
What it is:
An experimental exercise mimetic designed to enhance metabolic output without traditional training.
How it works:
Activates ERRα and ERRγ, regulators of mitochondrial biogenesis
Increases oxidative metabolism in skeletal muscle
Promotes fat burning without reducing caloric intake
Why it matters:
It targets endurance pathways at the cellular level, effectively shifting metabolism toward higher energy expenditure and fatty acid utilization.
3. Tesofensine
What it is:
A powerful oral appetite suppressant with central nervous system activity.
How it works:
Inhibits reuptake of dopamine, norepinephrine, and serotonin
Strongly suppresses hunger and enhances satiety
Why it matters:
By acting directly on hypothalamic appetite pathways, Tesofensine produces substantial reductions in caloric intake and rapid weight loss.
4. Tesamorelin
What it is:
A growth hormone–releasing hormone (GHRH) analog.
How it works:
Stimulates endogenous growth hormone secretion
Mobilizes stored fat, with a strong preference for visceral and organ fat
Improves lipid metabolism and body composition
Why it matters:
Tesamorelin is one of the few agents shown to significantly reduce deep abdominal fat without suppressing natural hormone rhythms.
5. MOTS-c
What it is:
A mitochondrial-derived peptide involved in metabolic regulation.
How it works:
Activates AMPK, the cell’s primary energy sensor
Enhances glucose uptake and fatty acid oxidation
Improves mitochondrial efficiency and metabolic flexibility
Why it matters:
MOTS-c works at the cellular level to improve how energy is produced and used, supporting fat loss and insulin sensitivity without appetite suppression.
6. 5-Amino-1MQ
What it is:
A metabolism-enhancing NNMT inhibitor.
How it works:
Inhibits nicotinamide N-methyltransferase (NNMT)
Raises NAD+ availability, supporting mitochondrial function
Increases fat oxidation and metabolic rate
Why it matters:
By preserving NAD+ and improving mitochondrial efficiency, 5-Amino-1MQ targets a core metabolic pathway linked to obesity and energy dysregulation.
