In the main event, Leon Edwards could have a title shot next if he gets past Belal Muhammad in a key welterweight contest.
Misha Cirkunov and Ryan Spann will clash in a light heavyweight contest in the co-main event.
Check out UFC Vegas 21 results below.
Main Card (ESPN+, 8 p.m. ET)
Leon Edwards vs. Belal Muhammad
Misha Cirkunov vs. Ryan Spann
Dan Ige vs. Gavin Tucker
Jonathan Martinez vs. Davey Grant
Manel Kape vs. Matheus Nicolau
Eryk Anders vs. Darren Stewart
Preliminary Card (ESPN+, 5 p.m.)
Angela Hill vs. Ashley Yoder
Charles Jourdain vs. Marcelo Rojo
Rani Yahya vs. Ray Rodriguez
Nasrat Haqparast vs. Rafa Garcia
Cortney Casey vs. JJ Aldrich
Jinh Yu Frey vs. Gloria de Paula
Matthew Semelsberger vs. Jason Witt
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