Been using letro since 2010. I don't use much as little as possible on a blast of aromatasing maybe need 3 to 3.5 mg per week at most. On trt dose I take 2 drops 2 or 3 times a week. Have it mixed in everclear at 4 mg per ml.
Approx 30 drops in 1 ml. So 2 drops = .26 mg
I never had a cholesterol problems I usually add drop at time if aromatasing and find sweet spot right after ed get better but before it starts up again. Ed is major sign that estro is too high or low. Or lack of woods during sleep. Signs of water and dryness come in the later after that.
Acne only indicates fluctuations I have had worse acne while estro too low.