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LA_Hardbody

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>From: "John Maynard" >To: "bigjosh" >Subject: TESTOSTERONE ESTERS
> >Table of Contents >================= > >1. WHAT AN ESTER IS,
AND HOW IT WORKS. >2. ACTIONS OF DIFFERENT ESTERS. >3. ESTER
PROFILES AND CONCLUSION > >One of the most misunderstood subjects
in the world of steroids is the >ester--the mechanism by which
injectable esterified steroids like >testosterone cypionate,
testosterone enanthate, and Sustanon work. If you >take a quick look
around the Internet you will probably find countless >articles that
consider one form of a steroid far more effective than >another.
Arguments over the superiority of cypionate to enanthate, or
>Sustanon to all other testosterones are of course very common. Such
>arguments are in all practicality, baseless. In this report we'll
take an >authoritative look at the ester and what specifically it
does to a >steroid. > > >1.- WHAT AN ESTER IS, AND HOW IT WORKS
> >I'm sure that if you have taken an interest in anabolic steroids
you have >noticed the similarities on the labeling of many drugs.
Let's look at >testosterone for example. One can find compounds like
testosterone >cypionate, enanthate, propionate, heptylate; caproate,
phenylpropionate, >isocaproate, decanoate, acetate, the list goes on
and on. In all such >cases the parent hormone is testosterone, which
had been modified by >adding an ester (enanthate, propionate etc.)
to its structure. The >following question arises: What is the
difference between the various >esterified versions of testosterone
in regards to their use in >bodybuilding? >An ester is a chain
composed primarily of carbon and hydrogen atoms. This >chain is
typically attached to the parent steroid hormone at the 17th >carbon
position (beta orientation), although some compounds do carry
>esters at position 3 (for the purposes of this article it is not
crucial >to understand the exact position of the ester).
Esterification of an >injectable anabolic/androgenic steroid
basically accomplishes one thing, >it slows the release of the
parent steroid from the site of injection. >This happens because the
ester will notably lower the water solubility of >the steroid, and
increase its lipid (fat) solubility. This will cause the >drug to
form a deposit in the muscle tissue, from which it will slowly
>enter into circulation as it is picked up in small quantities by the
>blood. Generally, the longer the ester chain, the lower the water
>solubility of the compound, and the longer it will take to for the
full >dosage to reach general circulation. >Slowing the release of
the parent steroid is a great benefit in steroid >medicine, as free
testosterone (or other steroid hormones) previously >would remain
active in the body for a very short period of time (typically
>hours). This would necessitate an unpleasant daily injection
schedule if >one wished to maintain a continuous elevation of
testosterone (the goal of >testosterone replacement therapy). By
adding an ester, the patient can >visit the doctor as infrequently
as once per month for his injection, >instead of having to
constantly re-administer the drug to achieve a >therapeutic effect.
Clearly without the use of an ester, therapy with an >injectable
anabolic/androgen would be much more difficult. >Esterification
temporarily deactivates the steroid molecule. With a chain >blocking
the 17th beta position, binding to the androgen receptor is not
>possible (it can exert no activity in the body). In order for the
compound >to become active the ester must therefore first be
removed. This >automatically occurs once the compound has filtered
into blood >circulation, where esterase enzymes quickly cleave off
(hydrolyze) the >ester chain. This will restore the necessary
hydroxyl (OH) group at the >17th beta position, enabling the drug to
attach to the appropriate >receptor. Now and only now will the
steroid be able to have an effect on >skeletal muscle tissue. You
can start to see why considering testosterone >cypionate much more
potent than enanthate makes little sense, as your >muscles are
seeing only free testosterone no matter what ester was used to
>deploy it. > > >2. - ACTIONS OF DIFFERENT ESTERS > >There are
many different esters that are used with anabolic/androgenic
>steroids, but again, they all do basically the same thing. Esters
vary >only in their ability to reduce a steroid's water solubility.
An ester >like propionate for example will slow the release of a
steroid for a few >days, while the duration will be weeks with a
decanoate ester. Esters have >no effect on the tendency for the
parent steroid to convert to estrogen or >DHT (dihydrotestosterone:
a more potent metabolite) nor will it effect the >overall
muscle-building potency of the compound. Any differences in >results
and side effects that may be noted by bodybuilders who have used
>various esterified versions of the same base steroid are just issues
of >timing. Testosterone enanthate causes estrogen related problems
more >readily than Sustanon, simply because with enanthate
testosterone levels >will peak and trough much sooner (1-2 week
release duration as opposed to >3 or 4). Likewise testosterone
suspension is the worst in regards to gyno >and water bloat because
blood hormone levels peak so quickly with this >drug. Instead of
waiting weeks for testosterone levels to rise to their >highest
point, here we are at most looking at a couple of days. Given an
>equal blood level of testosterone, there would be no difference in
the >rate of aromatization or DHT conversion between different
esters. There is >simply no mechanism for this to be possible.
>There is however one way that we can say an ester does technically
effect >potency; it is calculated in the steroid weight. The heavier
the ester >chain, the greater is its percentage of the total weight.
In the case of >testosterone enanthate for example, 250mg of
esterified steroid >(testosterone enanthate) is equal to only 180mg
of free testosterone. >70mgs out of each 250mg injection is the
weight of the ester. If we wanted >to be really picky, we could
consider enanthate slightly MORE potent than >cypionate (I know this
goes against popular thinking) as its ester chain >contains one less
carbon atom (therefore taking up a slightly smaller >percentage of
total weight). Propionate would of course come out on top of >the
three, releasing a measurable (but not significant) amount more
>testosterone per injection than cypionate or enanthate. > > >3.-
ESTER PROFILES > >Sustanon: The "king" of testosterone blends.
>The four different testosterone esters in this product certainly
look >appealing to the consumer, there is no denying that. But for
the athlete I >think it is all just a matter of marketing (Hell, why
buy one ester when >you can get four?). In clinical situations I can
see some strong uses for >it. If you were undergoing testosterone
replacement therapy for example, >you would probably find Sustanon a
much more comfortable option than >testosterone enanthate. You would
need to visit the doctor less frequently >for an injection, and
blood levels should be more steadily maintained >between treatments.
But for the bodybuilder who is injecting 4 ampules of >Sustanon per
week, there is no advantage over other testosterone products. >In
fact, the high price tag for Sustanon usually makes it a very poor
buy >in the face of cheaper testosterone enanthate/cypionate.
Bodybuilders >should probably stop looking at the four ester issue,
and stick with >totals (Sustanon is just a 250mg testosterone
ampule). Were enanthate to >be available for say $10 per amp of
250mg, and Sustanon priced nearly >double that, buying the Sustanon
would be like throwing money away. If you >could get nearly double
the milligram amount for the same price with >enanthate, this is the
better product to go with hands down. Leave the >high priced stuff
for the guys who don't know any better. > > >IN CONCLUSION >
>While the advent of esters certainly constitutes an invaluable
advance in >the field of anabolic steroid medicine, clearly you can
see that there is >no magic involved here. Esters work in a
well-understood and predictable >manner, and do not alter the
activity of the parent steroid in any way >other than to delay its
release. Although the lure surrounding various >steroid products
like testosterone cypionate, Sustanon, Omnadren etc. >certainly
makes for interesting conversation, realistically it just >amounts
to misinformation that the athlete would be better off ignoring.
>Testosterone is testosterone and anyone who is going to tell you one
ester >form of this (or any) hormone is much better than another one
should do a >little more research, and a lot less talking.
>Acetate: Chemical Structure C2H4O2. >Also referred to as Acetic
Acid; Ethylic acid; Vinegar acid; vinegar; >Methanecarboxylic acid.
Acetate esters delay the release of a steroid for >only a couple of
days. Contrary to what you may have read, acetate esters >do not
increase the tendency for fat removal. Again, there is no known
>mechanism for it to do so. This ester is used on oral primobolan
tablets >(metenolone acetate), Finaplix (trenbolone acetate) implant
pellets, and >occasionally testosterone. >Propionate: Chemical
Structure C3H6O2. >Also referred to as Carboxyethane; hydroacrylic
acid; Methylacetic acid; >Ethylformic acid; Ethanecarboxylic acid;
metacetonic acid; pseudoacetic >acid; Propionic Acid. Propionate
esters will slow the release of a steroid >for several days. To keep
blood levels from fluctuating greatly, >propionate compounds are
usually injected two to three times weekly. >Testosterone propionate
and methandriol dipropionate (two separate >propionate esters
attached to the parent steroid methandriol) are popular >items.
>Phenylpropionate: Chemical Structure C9H10O2. >Also referred to as
Propionic Acid Phenyl Ester. Phenylpropionate will >extend the
release of active steroid a few days longer than propionate. To
>keep blood levels even, injections are given at least twice weekly.
>Durabolin is the drug most commonly seen with a phenylpropionate
ester >(nandrolone phenylpropionate), although it is also used with
testosterone >in Sustanon and Omnadren. >Isocarpoate: Chemical
Structure C6H12O2. >Also referred to as Isocaproic Acid;
isohexanoate; 4-methylvaleric acid. >Isocaproate begins to near
enanthate in terms of release. The duration is >still shorter, with
a notable hormone level being sustained for >approximately one week.
This ester is used with testosterone in the >blended products
Sustanon and Omnadren. >Caproate: Chemical Structure C6H12O2. >Also
referred to as Hexanoic acid; hexanoate; n-Caproic Acid; n-Hexoic
>acid; butylacetic acid; pentiformic acid; pentylformic acid;
n-hexylic >acid; 1-pentanecarboxylic acid; hexoic acid; 1-hexanoic
acid; Hexylic >acid; Caproic acid. This ester is identical to
isocarpoate in terms of >atom count and weight, but is laid out
slightly different (Isocaproate has >a split configuration,
difficult to explain here but easy to see on >paper). Release
duration would be very similar to isocaproate (levels >sustained for
approximately one weak), perhaps coming slightly closer to
>enanthate due to its straight chain. Caproate is the slowest
releasing >ester used in Omnadren, which is why most athletes notice
more water >retention with this compound. >Enanthate: Chemical
Structure C7H14O2. >Also referred to as heptanoic acid; enanthic
acid; enanthylic acid; >heptylic acid; heptoic acid; Oenanthylic
acid; Oenanthic acid. Enanthate >is one of the most prominent esters
used in steroid manufacture (most >commonly seen with testosterone
but is also used in other compounds like >Primobolan Depot).
Enanthate will release a steady (yet fluctuating as all >esters are)
level of hormone for approximately 10-14 days. Although in >medicine
enanthate compounds are often injected on a bi-weekly or monthly
>basis, athletes will inject at least weekly to help maintain a
uniform >blood level. >Cypionate: Chemical Structure C8H14O2.
>Also referred to as Cyclopentylpropionic acid,
cyclopentylpropionate. >Cypionate is a very popular ester here in
the U.S., although it is >scarcely found outside this region. Its
release duration is almost >identical to enanthate (10-14 days), and
the two are likewise thought to >be interchangeable in U.S.
medicine. Althletes commonly hold the belief >than cypionate is more
powerful than enanthate, although realistically >there is little
difference between the two. The enanthate ester is in fact >slightly
smaller than cypionate, and it therefore releases a small >(perhaps
a few milligrams) amount of steroid more in comparison. >Decanoate:
Chemical Structure C10H20O2. >Also referred to as decanoic acid;
capric acid; caprinic acid; decylic >acid, Nonanecarboxylic acid.
The Decanoate ester is most commonly used >with the hormone
nandrolone (as in Deca-Durabolin) and is found in >virtually all
corners of the world. Testosterone decanoate is also the >longest
acting constituent in Sustanon, greatly extending its release
>duration. The release time with Decanoate compounds is listed to be
as >long as one month, although most recently we are finding that
levels seem >to drop significantly after two weeks. To keep blood
levels more uniform, >athletes (as they have always known to do)
will follow a weekly injection >schedule. >Undecylenate: Chemical
Structure C11H20O2. >Also referred to as Undecylenic acid;
Hendecenoic acid; Undecenoic acid. >This ester is very similar to
decanoate, containing only one carbon atom >more. Its release
duration is likewise very similar (approximately 2-3 >weeks),
perhaps extending a day or so past that seen with decanoate.
>Undecylenate seems to be exclusive to the veterinary preparation
Equipoise >(boldenone undecylenate), although there is no reason it
would not work >well in human-use preparations (Equipoise certainly
works fine for >athletes). Again, weekly injections are most common.
>Undecanoate: Chemical Structure C11H22O2. >Also referred to as
Undecanoic Acid; 1-Decanecarboxylic acid; Hendecanoic >acid;
Undecylic acid. Undecanoate is not a commonly found ester, and only
>appears to be used in the nandrolone preparation Dynabolan, and oral
>testosterone undecanoate (Andriol). Since this ester is chemically
very >similar to undecylenate (it is only 2 hydrogen atoms larger),
it has a >similar release duration (approximately 2-3 weeks).
Although this ester is >used in the oral preparation Andriol, there
is no reason to believe it >carries any properties unique of other
esters. Andriol in fact works very >poorly at delivering
testosterone, bolstering the idea that oral >administration is not
the idea use of esterified androgens. >Laurate: Chemical structure
C12H24O2. >Also referred to as Dodecanoic acid, laurostearic acid,
duodecyclic acid, >1-undecanecarboxylic acid, and dodecoic acid.
Laurate is the longest >releasing ester used in commercial steroid
production, although longer >acting esters do exist. Its release
duration would be closer to one month >than the other esters listed
above, although realistically we are probably >to expect a notable
drop in hormone level after the third week. Laurate is >exclusively
found in the veterinary nandrolone preparation Laurabolin, >perhaps
seen as slightly advantageous over a decanoate ester due to a less
>frequent injection schedule. Again athletes will most commonly
inject this >drug weekly, no doubt in part due to its low strength
(25mg/ml or >50mg/ml). > >
 
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