Good Question!!!
Sounds like you're referring to the idea of alternating low carb (higher fat) w/ high carb (low fat) meals over the course of a day.
The idea would be that you could increase insulin sensitivity in a matter of hours, which would provide a hormonal mileau (less insulin) that is not conducive to fat gain. It is still a matter of kcal in vs. kcal out when it comes to loseing or gaining fat, but we all know that hormones can play a big role in this.
Insulin, for instance, causes something called "futile" cycling, whereby energy is essentially loss b/c enzymes of carbohydrate metabolism are activated (ATP used) and enzymes that undo this activate are also active. (Thinking now of PFK kinase and PFK bisphosphatase.) This is basically like taking one step forward and then o1 step back - end result is simply energy loss but in terms of the metabolic processes involving the carbs, you're back where y ou started. This is one of the things that causes the thermic response to feeding / eating.
Anyway, hypothetically, you could take advantage of such things by eating a low carb meal in between a high carb meal and do a better job of handling the carbs (less fat storage, more glycogen storage) b/c you have had enough time to restore / improve insulin sensitivity during the 5-6 hr between carb meals. (Whereas this would not happend eating a carb containing meal every 2-3 hr).
Haven't seen it demonstrated in humans, but there might be something in the animal lit. which I haven't loooked into for a long time. A guy named Flatt wouuld be the one who would have done it (with mice, probably).
But, like y ou said, hard as nails, genetics is the overriding factor.
FYI< I recall reading the Lee Labrada used to eat this way. I also saw Doggcrapp post recently that he has his trainees do the same. (He also includes a non-carb meal at night, giving the time during sleep to do the insulin sensitivity trick, but varies the time of the alst carb containing meal according to the althete's genetics and propensityu for putting on fat. He seems to have pretty good results.)
-Randy