new study suggests igf-i good for cutting

new studies suggest igf-i good for cutting

i'm a little surprised. i can't remember how this translates to the breakdown pathways activated during dieting though. i don't remember which ones are most responsible... if you guys are curious, let me know and i'll research it further.

http://endo.endojournals.org/cgi/rapidpdf/en.2004-0869v1
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15661854
http://www.jci.org/cgi/content/full/115/2/451

"Additional experiments showed that similar mechanisms were responsible for the effect of IGF-I in muscle from non-burned rats. Taken together with recent reports in the literature, the present results suggest that IGF-I inhibits protein breakdown in skeletal muscle by multiple mechanisms, including PI3K/Akt-mediated inactivation of GSK-3beta and Foxo transcription factors."

Im wondering if IGF could be used in treatment of hypercortisolism/cushings .........at least to prevent muscle loss.

"Our results show therefore that IGF-I gene transfer by electroporation prevents muscle atrophy in glucocorticoid-treated rats. "

This does show it's a great post cycle supplement.......especially since post cycle we have a chaotic amount of cortisol released.