I am going to do twice a day 20/20 in AM then 20/20 in PM. I could do 4 times a day if I don't bilaterally apply twice a day.... That'd be crazy. Every 6 hours... 7am, 1pm, 7pm, 1am. 20mcg every 6 hours... that'd be freaking intense. I think at that point my feet, hands, and organs would start growing along with my forehead haha.