I also agree with B2S. The reasoning behind the splitting is to have more consistent levels since it is so fast-acting in the body. The 3 day on 1 day off is more like the body's natural pulses so it keeps the body from getting used to it, and you'd be able to use it longer.
Twice a day would probably make you less likely to have a blood sugar drop as well. You would in essence be taking half as much at a time and half as likely to go hypo, or at least that seems logical.
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