OK - calling on the collective mind of MC members - *really* poor response to gear

D

Doctor9

MuscleChemistry Registered Member
OK - I'm not an MD (My nickname is a Dr. Who reference) but I *am* a B.Sc. Chemistry with a smattering of other sciences tossed in. I know when I've hit a problem I can't solve without help, and this one has been bugging me for years.

It is possible to have a really poor response to gear for many compounds but still maybe have a few that do work really well? This is what I'm hoping, but not sure if it's likely.

I know people and train with people who have been using various test esters, for example, and make *significant* gains pretty quickly. I take the same ones, and the gains are minimal at best.

Before you all go off on the "your gear is bunk" train, it is the *same* gear that they are using. Not the same supplier, not the same ester...the *same* actual batch. How do I know? I prepared it!

My response to several compounds I have tried over the years can be described as limited. I don't get the acne or get horny or the aggressiveness that many get on test...on the other hand, I don't get great growth off it either. Even tren from a reliable source - slight response, but nothing of major consequence.

At one point I thought maybe I had particularly high SGBH, so tried an experiment with proviron - nada.

Even such things as Anadrol-50, again from a reliable source...nothing...nada.

I presume there is *something* I will respond to - or maybe I'm just cursed to get very slow improvements.

So, I'm tossing this out there - hoping our collective mind will come up with something.

Any ideas?

Doctor9
 
What are the time frames that you have experimented with and what is your total protein intake? Also be real and what is your alcohol and diet intake like. Some are hard gainers, some are just hard to come to terms with reality. What are your experiences with you?
 
The first thing I would look at is diet and training. I really can't come to a conclusion as to what else would cause the "no side effects" aspect. If you've been using gear for years then I would assume your receptors are just need to refresh. Androgens attach themselves to the receptors and once they are attached they don't typically continue to provide the data to the cells to continue growth. Off time or moderate test dosing will allow the old inactive or drained androgens to detach from the receptor and increase available receptor sites when you do decide to blast and cruise or do another cycle.

If you got all your ducks in a row already then from this point I would have to say that everyones body chemistry is different and just continue tweaking and modifying your workouts, diet and cycles till it starts working like you want.
 
Yeah, gonna need a few stats to answer better. Age, diet and training, and what gear specifically and length of time, dosage etc....
 
Dude you should see an increase in weight by about 5-10lbs just by pinning good test. You don't even have to lift a finger. I bet you are injecting subq and the shit is just sitting under your skin. You gotta go deep intramuscular. If you are then either the gear is "you know what" or you aint eating enough. If you can't grow on anadrol it ain't anadrol. Pm me where you got the anadrol. I ain't shoppin there. All kidding aside there are to many questions that haven't been answered.:cry:
 
if you're brewing your own and others are responding except you, you may be a non responder. We all know many people respond to supplements based on the lack of said supplement in their body. If you have a glutamine deficiency you would respond better to someone who does not, same goes with creatine, vitamin and minerals.

ive never heard of a non responder to gear though, something will happen. Especially anadrol.
 
Doctor9 said:
OK - I'm not an MD (My nickname is a Dr. Who reference) but I *am* a B.Sc. Chemistry with a smattering of other sciences tossed in. I know when I've hit a problem I can't solve without help, and this one has been bugging me for years.

It is possible to have a really poor response to gear for many compounds but still maybe have a few that do work really well? This is what I'm hoping, but not sure if it's likely.

I know people and train with people who have been using various test esters, for example, and make *significant* gains pretty quickly. I take the same ones, and the gains are minimal at best.

Before you all go off on the "your gear is bunk" train, it is the *same* gear that they are using. Not the same supplier, not the same ester...the *same* actual batch. How do I know? I prepared it!

My response to several compounds I have tried over the years can be described as limited. I don't get the acne or get horny or the aggressiveness that many get on test...on the other hand, I don't get great growth off it either. Even tren from a reliable source - slight response, but nothing of major consequence.

At one point I thought maybe I had particularly high SGBH, so tried an experiment with proviron - nada.

Even such things as Anadrol-50, again from a reliable source...nothing...nada.

I presume there is *something* I will respond to - or maybe I'm just cursed to get very slow improvements.

So, I'm tossing this out there - hoping our collective mind will come up with something.

Any ideas?

Doctor9
Click to expand...


You sound like me. Tried anadrol.. nothing. Don't gain all the weight like others do with dbol. I maybe get a little more on test, but not a lot. I've never tried proviron to see if I had high SHBG. I do seem to respond well enough to tren, but I get mostly ripped and not much of a weight gain. IMO, I think we have high myostatin. The best I ever looked and the biggest I've ever been was when I tried some actual myostatin inhibitor, acvr2b, from a real biopharma company. I can say for my activity level and calorie intake, I should be 220-230 easily, but I'm not. Just reaching 205 now. Still trying to figure it all out.
 
OK - calling on the collective mind of MC members - *really* poor response to...

I'm nearly 100% certain that the issue that you're experiencing is more obvious than you think.
Lots of people say you need 8 hours of sleep... I need 9 hours 5 days a week and 11 hours on the other two days.
Lots of people say 1 gram of protein per pound of body weight. I eat nearly 3lbs of meat a day,10 eggs, and 80g of whey protein. That's daily.
If I am stressed I lose weight. Period.
You are missing something.
Write down everything you eat, how much and how well you sleep, and how your stress levels are.
So many people say that they eat 300g of protein a day, but what they aren't saying is 200g comes from shakes.
You need solid clean food. My body struggles with processed food. It just makes me bloated.
Take a step back and an honest assessment. You may not be Mr Olympia material, but I've seen guys make CRAZY gains after years of stagnation when they got their act together.
 
BigZ said:
You sound like me. Tried anadrol.. nothing. Don't gain all the weight like others do with dbol. I maybe get a little more on test, but not a lot. I've never tried proviron to see if I had high SHBG. I do seem to respond well enough to tren, but I get mostly ripped and not much of a weight gain. IMO, I think we have high myostatin. The best I ever looked and the biggest I've ever been was when I tried some actual myostatin inhibitor, acvr2b, from a real biopharma company. I can say for my activity level and calorie intake, I should be 220-230 easily, but I'm not. Just reaching 205 now. Still trying to figure it all out.
Click to expand...

I am very much the same way. The Dude has some really solid advice right there and I for one am taking that advice and running with it; adding a little advice from glycoman as well... ;)
 
Well, I know for a *fact* my diet is definitely a limiting factor in my growth - my current employment *really* does not lend itself to getting to eat on a regular basis - there are even days where eating at prescribed break times is an issue. *sigh* I'm still wondering about the combined lack of gains *and* sides - is it *possible* I just have low receptor levels? I do *get* gains...just not like some people who explode on nearly any dose. BigZ and Austin311 - not that I'm happy you have the same issue, but I am glad to hear I'm not the *only* one for whom the magic is less than magical.

At *least* IGF-1 seems to help a bit :)

I'm sure at some point I'll get everything dialed in...*and* find something I actually respond well to - it must exist.

Come to think of it, the *only* time I had increased aggressiveness (mini-roid rage :p) was years ago on an M1-T/Tribulus cycle...which most people would laugh at.

Maybe I just need to accept that in this way, like several others :p, I'm just weird ;) and make the best of it.

Doctor9
 
Get a psycho training partner, train compound movements and eat 3 lbs of chicken and 8 cups of rice a day. You will grow on 300 mg/w of Test E.
 
Somebody on here said recently that steroids make increased protien synthesis possible and that's what makes the muscles grow. I guess if your body isn't getting adequate fuel including protien from your diet, all the gear you can give it won't give you the gains you're looking for since there's not enough fuel. Maybe your body is doing all it can with the food it's getting. ..

I get the issue w work not being conducive to a gaining diet; I had a job like that. Was always on my feet, always moving, and every time I took a bite had to jump up and go. Got very lean on that job but didn't putbon much muscle, despite hwavy training!

Sent from my SM-G900V using Tapatalk
 
Dude beat me to it. Diet training all factors bro. IF SHGB is a factor Trestolone will be an answer bc it's stronger than Test & cannot be bound to SHGB. But either way Dude's 1000% & Doc ur LIVING PROOF AAS are no miracle drug or walk in the park (NO offence) Androgen Reseptors are also a factor too low you don't grow as well.
 
The Dude said:
I'm nearly 100% certain that the issue that you're experiencing is more obvious than you think.
Lots of people say you need 8 hours of sleep... I need 9 hours 5 days a week and 11 hours on the other two days.
Lots of people say 1 gram of protein per pound of body weight. I eat nearly 3lbs of meat a day,10 eggs, and 80g of whey protein. That's daily.
If I am stressed I lose weight. Period.
You are missing something.
Write down everything you eat, how much and how well you sleep, and how your stress levels are.
So many people say that they eat 300g of protein a day, but what they aren't saying is 200g comes from shakes.
You need solid clean food. My body struggles with processed food. It just makes me bloated.
Take a step back and an honest assessment. You may not be Mr Olympia material, but I've seen guys make CRAZY gains after years of stagnation when they got their act together.
Click to expand...
Dude you bring a lot of knowledge to this forum! Thanks for the great post.

I'm similar in the stress and sleep regard.
 
Doctor9 said:
Well, I know for a *fact* my diet is definitely a limiting factor in my growth - my current employment *really* does not lend itself to getting to eat on a regular basis - there are even days where eating at prescribed break times is an issue. *sigh* I'm still wondering about the combined lack of gains *and* sides - is it *possible* I just have low receptor levels? I do *get* gains...just not like some people who explode on nearly any dose. BigZ and Austin311 - not that I'm happy you have the same issue, but I am glad to hear I'm not the *only* one for whom the magic is less than magical.

At *least* IGF-1 seems to help a bit :)

I'm sure at some point I'll get everything dialed in...*and* find something I actually respond well to - it must exist.

Come to think of it, the *only* time I had increased aggressiveness (mini-roid rage :p) was years ago on an M1-T/Tribulus cycle...which most people would laugh at.

Maybe I just need to accept that in this way, like several others :p, I'm just weird ;) and make the best of it.

Doctor9
Click to expand...

Yep, there are a few of us out there. :) Diet has been a limiting factor for me in the past. I'm getting better at it. I've noticed that I do much better with whole foods like The Dude says. Even then, I still don't explode on doses either. No real sides either except for acne if I don't balance out the estrogen/test equation. I can take more than 1g/week of test and not need any estrogen inhibitor. That right there would possibly tell you that the body isn't responding as much to the gear. I don't know that it's receptor levels. I'm of the opinion that it's high myostatin. IGF helps me a TON.
 
I don't gain a lot of weight no matter what I take either. I'll gain strength but not much in the weight department. My body composition will change but I don't gain much primarily because I don't eat enough. I know this is my problem and I've come to realize because I have such a hard time force feeding myself that I'll always be strong for my size and never be big. It was a hard pill to swallow, but i can live with it.
 
I never got anything from Anadrol myself either. I switched to D-bol and KABOOM! Blew up 40lbs in 4 weeks and put 100lbs on my max bench press....of course that was when I was 25 and only my 2nd cycle ever.....and I was eating like a horse too. (oh those were the days).

That said, I recently tried Havoc and then M1T and got nada once again. I took the recommended dosage for both but just didn't get anything. Over time we all learn how our body will react and ultimately figure out what works best. Can't stress enough just like the others that have replied...DIET is everything! Gotta eat to grow. Think about it, if we spend 1-2 hours a day in the gym...that leaves us with 22 hours in the day to make the decisions about what and when we are going to eat. Gotta feed the beast ya know...a Ferrari won't go very far on an empty tank of gas.
 
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