Drugs and Supplements[h=1]Whey protein[/h]
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[h=2]Safety[/h]The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
[h=4]Allergies[/h]Avoid in people with known allergy or sensitivity to milk or milk products, including cow's milk, sheep's milk, goat's milk, and mare's milk.
Allergic reactions (including diarrhea, failure to thrive, infant colic, rash, and vomiting) have been reported with exposure to whey.
[h=4]Side Effects and Warnings[/h]Whey protein is likely safe for most adults when used in amounts recommended by the manufacturer.
Whey protein is possibly safe when taken by mouth as a single dose of up to 50 grams, or when 30 grams is taken by mouth daily for six months.
Whey protein may cause abnormal heart rhythms, changes in cholesterol levels, headache, increased diabetes risk, increased fracture or osteoporosis risk, kidney dysfunction, liver damage, stomach or intestine symptoms (acid reflux, bloating, constipation, cramps, gas, increased bowel movements, movement problems, nausea, reduced appetite, swelling of limbs, and upset stomach), and thirst.
Whey protein may lower blood sugar levels. Caution is advised in people with diabetes or low blood sugar, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.
Whey protein may increase the risk of bleeding. Caution is advised in people with bleeding disorders or in those taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.
Whey protein may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system.
Whey protein may cause low blood pressure. Caution is advised in people with low blood pressure or in those taking drugs or herbs and supplements that lower blood pressure.
Drowsiness or sedation may occur. Use caution if driving or operating heavy machinery.
Use cautiously in people who take medications, including agents that affect the immune system and agents that lower cholesterol.
Use cautiously in people with stomach or intestine disorders.
Avoid in people with known allergy or sensitivity to milk or milk products, including cow's milk, sheep's milk, goat's milk, and mare's milk.
Avoid in people who are avoiding the use of dairy products.
Avoid using whey protein long-term and in excessive amounts.
Only approved sources of whey protein should be used in infant formulas.
[h=4]Pregnancy and Breastfeeding[/h]There is a lack of scientific evidence on the use of whey protein during pregnancy or breastfeeding. Only approved sources of whey protein should be used in infant formulas. Allergic reactions have been reported with exposure to whey protein, including diarrhea, failure to thrive, infant colic, and rash.
[h=2]Interactions[/h][h=4]Interactions with Drugs[/h]Whey protein may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Whey protein may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.
Whey protein may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Whey protein may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be altered in the blood, and may cause altered effects or potentially serious adverse reactions. People using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Whey protein may also interact with agents that affect appetite, agents that affect blood vessel width, agents that affect the immune system, agents that promote breast milk, agents that treat abnormal heart rhythms, agents that treat parasites or worms, albendazole, alcohol, alendronate, anti-allergy agents, antibiotics, anticancer agents, anti-inflammatory agents, antiulcer agents, antiviral agents, bone agents, cholesterol-lowering agents, dental agents, fertility agents, heart agents, hormonal agents, indomethacin, iron salts, kidney agents, levodopa, liver agents, lung agents, mood-altering agents, musculoskeletal agents, nervous system agents, pain relievers, performance enhancement agents, skin agents, stomach and intestine agents, weight loss agents, and wound-healing agents.
[h=4]Interactions with Herbs and Dietary Supplements[/h]Whey protein may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Whey protein may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.
Whey protein may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Whey protein may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be altered in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.
Whey protein may also interact with amino acids, anti-allergy herbs and supplements, antibacterials, anticancer herbs and supplements, anti-inflammatory herbs and supplements, antioxidants, antiulcer herbs and supplements, antiviral herbs and supplements, bone herbs and supplements, calcium, cholesterol-lowering herbs and supplements, colostrum, copper, creatine, dental herbs and supplements, fertility herbs and supplements, folic acid, fructooligosaccharides, herbs and supplements used for the heart, herbs and supplements that affect appetite, herbs and supplements that affect blood vessel width, herbs and supplements that affect the immune system, herbs and supplements that promote breast milk, herbs and supplements that treat abnormal heart rhythms, herbs and supplements that treat parasites or worms, hormonal herbs and supplements, iron, kidney herbs and supplements, leucine, limonene, liver herbs and supplements, lung herbs and supplements, maltodextrin, mood-altering herbs and supplements, musculoskeletal herbs and supplements, nervous system herbs and supplements, omega-3 fatty acids, pain relievers, performance enhancement herbs and supplements, probiotics, selenium, skin herbs and supplements, soy, spirulina, stomach and intestine herbs and supplements, vitamins, weight loss herbs and supplements, wound-healing herbs and supplements, and zinc.
[h=2]Methodology[/h]This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
[h=2]Selected references[/h]
<nav role="navigation" aria-label="Navigation Menu" class="resizable" style="z-index: 999;">
</nav>
[h=2][/h]
[h=2]Safety[/h]The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
[h=4]Allergies[/h]Avoid in people with known allergy or sensitivity to milk or milk products, including cow's milk, sheep's milk, goat's milk, and mare's milk.
Allergic reactions (including diarrhea, failure to thrive, infant colic, rash, and vomiting) have been reported with exposure to whey.
[h=4]Side Effects and Warnings[/h]Whey protein is likely safe for most adults when used in amounts recommended by the manufacturer.
Whey protein is possibly safe when taken by mouth as a single dose of up to 50 grams, or when 30 grams is taken by mouth daily for six months.
Whey protein may cause abnormal heart rhythms, changes in cholesterol levels, headache, increased diabetes risk, increased fracture or osteoporosis risk, kidney dysfunction, liver damage, stomach or intestine symptoms (acid reflux, bloating, constipation, cramps, gas, increased bowel movements, movement problems, nausea, reduced appetite, swelling of limbs, and upset stomach), and thirst.
Whey protein may lower blood sugar levels. Caution is advised in people with diabetes or low blood sugar, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.
Whey protein may increase the risk of bleeding. Caution is advised in people with bleeding disorders or in those taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.
Whey protein may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system.
Whey protein may cause low blood pressure. Caution is advised in people with low blood pressure or in those taking drugs or herbs and supplements that lower blood pressure.
Drowsiness or sedation may occur. Use caution if driving or operating heavy machinery.
Use cautiously in people who take medications, including agents that affect the immune system and agents that lower cholesterol.
Use cautiously in people with stomach or intestine disorders.
Avoid in people with known allergy or sensitivity to milk or milk products, including cow's milk, sheep's milk, goat's milk, and mare's milk.
Avoid in people who are avoiding the use of dairy products.
Avoid using whey protein long-term and in excessive amounts.
Only approved sources of whey protein should be used in infant formulas.
[h=4]Pregnancy and Breastfeeding[/h]There is a lack of scientific evidence on the use of whey protein during pregnancy or breastfeeding. Only approved sources of whey protein should be used in infant formulas. Allergic reactions have been reported with exposure to whey protein, including diarrhea, failure to thrive, infant colic, and rash.
[h=2]Interactions[/h][h=4]Interactions with Drugs[/h]Whey protein may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Whey protein may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.
Whey protein may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Whey protein may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be altered in the blood, and may cause altered effects or potentially serious adverse reactions. People using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Whey protein may also interact with agents that affect appetite, agents that affect blood vessel width, agents that affect the immune system, agents that promote breast milk, agents that treat abnormal heart rhythms, agents that treat parasites or worms, albendazole, alcohol, alendronate, anti-allergy agents, antibiotics, anticancer agents, anti-inflammatory agents, antiulcer agents, antiviral agents, bone agents, cholesterol-lowering agents, dental agents, fertility agents, heart agents, hormonal agents, indomethacin, iron salts, kidney agents, levodopa, liver agents, lung agents, mood-altering agents, musculoskeletal agents, nervous system agents, pain relievers, performance enhancement agents, skin agents, stomach and intestine agents, weight loss agents, and wound-healing agents.
[h=4]Interactions with Herbs and Dietary Supplements[/h]Whey protein may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Whey protein may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.
Whey protein may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Whey protein may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be altered in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.
Whey protein may also interact with amino acids, anti-allergy herbs and supplements, antibacterials, anticancer herbs and supplements, anti-inflammatory herbs and supplements, antioxidants, antiulcer herbs and supplements, antiviral herbs and supplements, bone herbs and supplements, calcium, cholesterol-lowering herbs and supplements, colostrum, copper, creatine, dental herbs and supplements, fertility herbs and supplements, folic acid, fructooligosaccharides, herbs and supplements used for the heart, herbs and supplements that affect appetite, herbs and supplements that affect blood vessel width, herbs and supplements that affect the immune system, herbs and supplements that promote breast milk, herbs and supplements that treat abnormal heart rhythms, herbs and supplements that treat parasites or worms, hormonal herbs and supplements, iron, kidney herbs and supplements, leucine, limonene, liver herbs and supplements, lung herbs and supplements, maltodextrin, mood-altering herbs and supplements, musculoskeletal herbs and supplements, nervous system herbs and supplements, omega-3 fatty acids, pain relievers, performance enhancement herbs and supplements, probiotics, selenium, skin herbs and supplements, soy, spirulina, stomach and intestine herbs and supplements, vitamins, weight loss herbs and supplements, wound-healing herbs and supplements, and zinc.
[h=2]Methodology[/h]This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
[h=2]Selected references[/h]
- Abrahao V. Nourishing the dysfunctional gut and whey protein. Curr.Opin.Clin.Nutr Metab Care 2012;15(5):480-484.
- Brewer MS. Reducing the fat content in ground beef without sacrificing quality: a review. Meat.Sci 2012;91(4):385-395.
- Burd NA, Andrews RJ, West DW, et al. Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men. J Physiol 1-15-2012;590(Pt 2):351-362.
- Gouni-Berthold I, Schulte DM, Krone W, et al. The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial. Br.J Nutr 2012;107(11):1694-1706.
- Gunnerud UJ, Heinzle C, Holst JJ, et al. Effects of pre-meal drinks with protein and amino acids on glycemic and metabolic responses at a subsequent composite meal. PLoS.One. 2012;7(9):e44731.
- Gunnerud U, Holst JJ, Ostman E, et al. The glycemic, insulinemic and plasma amino acid responses to equi-carbohydrate milk meals, a pilot- study of bovine and human milk. Nutr J 2012;11:83.
- Jain SK. L-cysteine supplementation as an adjuvant therapy for type-2 diabetes. Can.J Physiol Pharmacol 2012;90(8):1061-1064.
- Kerasioti E, Kiskini A, Veskoukis A, et al. Effect of a special carbohydrate-protein cake on oxidative stress markers after exhaustive cycling in humans. Food Chem Toxicol. 2012;50(8):2805-2810.
- Kreger JW, Lee Y, and Lee SY. Perceptual changes and drivers of liking in high protein extruded snacks. J Food Sci 2012;77(4):S161-S169.
- Mortensen LS, Holmer-Jensen J, Hartvigsen ML, et al. Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. Eur.J Clin.Nutr 2012;66(7):799-805.
- Oftedal OT. The evolution of milk secretion and its ancient origins. Animal. 2012;6(3):355-368.
- Ramos OL, Fernandes JC, Silva SI, et al. Edible films and coatings from whey proteins: a review on formulation, and on mechanical and bioactive properties. Crit Rev.Food Sci Nutr 2012;52(6):533-552.
- Ross EK, Gray JJ, Winter AN, et al. Immunocal(R) and preservation of glutathione as a novel neuroprotective strategy for degenerative disorders of the nervous system. Recent Pat CNS.Drug Discov. 2012;7(3):230-235.
- Sheikholeslami Vatani D and Ahmadi Kani Golzar F. Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training. Appetite 2012;59(3):673-678.
- van Calcar SC and Ney DM. Food products made with glycomacropeptide, a low-phenylalanine whey protein, provide a new alternative to amino Acid-based medical foods for nutrition management of phenylketonuria. J Acad.Nutr Diet. 2012;112(8):1201-1210.
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