<h1>Deca- Durabolin (Nandrolone decanoate, ND) treatment causes damage in the male reproductive system. </h1>
Rutin (RT) is a naturallyoccurring flavonoid glycoside that has antioxidant and anti-inflammatory properties. This study aimed to investigate effects of rutinagainst ND-induced reproductive toxicity in male rats. Forty adult male rats were used. The control group received olive oil with oralgavage during 6 weeks. ND Groups received different doses (25, 50, 100 mg Kg-1, i.m.). RT + ND groups received RT (50 mg kg -1, P.o.)during 6 weeks, associated with (25,50,100 mg Kg-1, i.m.). Biochemical (total protein, testosterone, MDA, SOD and CAT), histological,histochemical and immunohistochemical studies of testicles were evaluated. ND treatment increased the oxidative stress andinduced testicular degeneration and apoptosis when compared to the control group. However, RT treatment relieves these sideeffects when compared to the ND group alone. It is concluded that RT treatment may reduce ND-induced reproductive toxicity as apotential antioxidant compound.Keywords: Nandrolone decanoate- Testes- rutin- apoptosis- oxidative stress.
Rutin (RT) is a naturallyoccurring flavonoid glycoside that has antioxidant and anti-inflammatory properties. This study aimed to investigate effects of rutinagainst ND-induced reproductive toxicity in male rats. Forty adult male rats were used. The control group received olive oil with oralgavage during 6 weeks. ND Groups received different doses (25, 50, 100 mg Kg-1, i.m.). RT + ND groups received RT (50 mg kg -1, P.o.)during 6 weeks, associated with (25,50,100 mg Kg-1, i.m.). Biochemical (total protein, testosterone, MDA, SOD and CAT), histological,histochemical and immunohistochemical studies of testicles were evaluated. ND treatment increased the oxidative stress andinduced testicular degeneration and apoptosis when compared to the control group. However, RT treatment relieves these sideeffects when compared to the ND group alone. It is concluded that RT treatment may reduce ND-induced reproductive toxicity as apotential antioxidant compound.Keywords: Nandrolone decanoate- Testes- rutin- apoptosis- oxidative stress.