IGF

I just felt like saying this. I did a search on IGF on a couple of boards and it's amazing how this drug exploded. Two and a half years ago (before using gear), I was working with this stuff by the truck load doing cancer research. I remember ordering like 100 vials some weeks for upcoming experiments I was going to conduct. If I only knew back then. It would have been sooo easy to walk out with 10 vials a day of this stuff!! Still, I would not even think of touching this stuff. Seeing personally what it does in the cells I introduced it to, I really hope that you guys that are using it know what you're doing. I'm not trying to scare anyone because you're going to do it anyway, but I just needed to say that. As for research, yes I got that research published in the Journal of Cellular Biochemistry 83:204-217 (2001) under my name if anyone cares. Most of the data about IGF was taken out of the published paper. You don't get future grants by publishing negative experiments.

another drug that I worked on in that paper was called Vasopressin. I'm surprised that it hasn't caught on yet like IGF. The hypertrophy it caused in cells was amazing.

I think there are some real questions about IGF and if you have some experience with it I'd like to hear about it. I'd at least like to know as much as I can about something I'm contemplating using. All I've been able to come up with that I can understand, is that it can thicken the wall of the intestine, and that it might somehow protect existing cancer cells there. I've seen what appear to be conflicting studies that it prevents or promotes prostrate cancer.
Any additional light you can shed would be appreciated.

Does it cause cell hypertrophy or cell division or both?

I also thought that it only worked on muscle cells.

Got to go pissing on the parade huh bro ??
J/K Bro if you have insight please share, all I have read were great things, and that has me a minute away from odering some.
Please give me the lowdown.

I feel a disturbance in the force!


Meanwhile tell me more about his Vasopressin stuff. I had my crack research team get right on this. So far this is what they came up with:


The single most important effect of antidiuretic hormone is to conserve body water by reducing the output of urine.

Vasopressin at physiologic concentrations mobilized 60% of cell-associated Ca2+ and decreased protein synthesis by 50% within 20-30 min

Longer exposures to vasopressin were invariably accompanied by increased rates of protein synthesis.


Would this cause a self-poisoning state or are we talking about something within reason (now that's a loaded statement!)?

Not sure if I'd want to be the lab rat for this one......

As a hormone,vasopressin has roles as an antidiuretic, and in adrenocorticotropic hormone (ACTH)-releasing activity. Vasopressin is a potent vasoconstrictor that increases blood pressure and systemic vascular resistance, and decreases cardiac output, heart rate, left ventricular oxygen consumption, and myocardial contractility. With regard to cerebral blood flow, vasopressin not only increases flow to a greater degree than epinephrine, it also improves cerebral oxygenation and decreases venous hypercarbia (Prengal, Lindner, & Keller, 1996).

I will post my paper tomorrow when I get in at work. It will be mostly talking about Vasopressin as the IGF info was not published in the paper due to bad experimental data.

About IGF. BiggerStronger~ it causes the cells to undergo mitosis which is the division of cells. It changes your DNA makeup. An interesting fact I remember was that the process of mitosis that the cells go under is not an even mitosis. Mitosis is supposed to be the splitting of cells causing two identical cells. IGF causes mitosis irradically (sp?). Which now means that you have just introduced NEW cells to your system which then will undergo mitosis with more IGF taken.

Again I will post more info when I get back in work tomorrow.

I would be more confortable taking Vasopressin as it only causes hypertrophy and no mitosis of cells.

gymrat said:

I would be more confortable taking Vasopressin as it only causes hypertrophy and no mitosis of cells.

Click to expand...

Yes, but to a great extent GH does the same thing being a precursor to IGF.

I do suppose that there is some governor that controls how much GH converts into IGF and by directly taking IGF you are going past this limit. But isn't that the whole point to taking it?

BTW, this is the type of discussion you just don't get on most other boards! Good Post gymrat!

Did you work with regular IGF1 or IGF1 Long R3?

I guess the main concern with IGF1 would be the high risk of abnormal cells forming and causing some sort of cancer growth.

I thought that IGF1 acts like insulin in the liver and only has a growth affect on muscle? So only the only chance of a cancer like growth would be within the muscle (including smooth muscle) or am I totally off base?

Well he said he worked with igf 10 years ago, and Long r3 version is pretty new so probably the regular igf.

As far as igf and how it relates to cancer most info seems to point to igf increasing proliferation of cancer cells already existing.


Cancer Lett. 2003 Jun 10;195(2):127-37. Related Articles, Links


The insulin-like growth factor system and cancer.

LeRoith D, Roberts CT.

Diabetes Branch, Room 8D12, Building 10, National Institutes of Health MSC 1758, 20892-1758, Bethesda, MD, USA

The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body. The system also has powerful anti-apoptotic effects. More recently, evidence has accrued to demonstrate that the IGFs play an important role in cancer. Individuals with serum IGF-II levels in the upper quartile of the normal range (and IGF binding protein-3 levels in the lower quartiles) have a relative risk for developing breast, prostate, colon and lung cancer. IGF-II is commonly expressed by tumor cells and may act as an autocrine growth factor; occasionally even reaching target tissues and causing tumor-induced hypoglycemia. The IGF-I receptor is commonly (though not always) overexpressed in many cancers, and many recent studies have identified new signaling pathways emanating from the IGF-I receptor that affect cancer cell proliferation, adhesion, migration and cell death; functions that are critical for cancer cell survival and metastases.In this review, many aspects of the IGF system and its relationship to cancer will be discussed.

PMID: 12767520 [PubMed - in process]

Wanted to get the full article but it cost $30.00 have to wait til payday.

Gastroenterology. 1993 Oct;105(4):1218-37. Related Articles, Links


Insulinlike growth factors and binding proteins in colon cancer.

Singh P, Rubin N.

Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston.

Insulinlike growth factors (IGFs) express anabolic and mitogenic activity on wide variety of cells. Besides endocrine effects, IGFs have major autocrine and paracrine effects on many cellular functions. Two factors that significantly affect the extent of cellular response to IGFs include the membrane receptors for IGFs and the soluble binding proteins (BPs), which modulate the action of IGFs at the receptor level. IGFs, IGF receptors, and IGFs and their BPs (IGF-BPs) thus constitute three components of the IGF system. A role of IGFs in the transformation and proliferation of cancer cells has become increasingly evident in the past few years. Studies from several laboratories show that all three components of the IGF system may play an important role in the proliferation of colon cancers. It was recently shown that the relative expression of IGFs and IGF/BPs may critically control the metastatic potential of colon cancers. The purpose of this article is to summarize our current knowledge of the IGF system and to present support for a significant role of IGFs in the initiation and growth of colon cancers. The expression and structural aspects of IGFs, their receptors, and BPs are outlined first, followed by a discussion of the role of IGFs in gastrointestinal functions and in colon cancers.

Publication Types:
• Review
• Review, Tutorial

PMID: 7691674 [PubMed - indexed for MEDLINE]

Sounds like using igf if you have cancer is a bad idea, but if you don't then I don't see anything saying it will cause cancer...

Of course I just started looking...

(edited) look's like some scientist think I spoke too soon:

J La State Med Soc. 1999 Apr;151(4):218-23. Related Articles, Links


Insulin-like growth factors and cancer.

Yu H, Berkel H.

Section of Cancer Prevention and Control, Feist-Weiller Cancer Center at Louisiana State University Medical Center, Shreveport, USA.

Insulin-like growth factors (IGFs) regulate important cellular activities involving cell proliferation, differentiation, and apoptosis. Emerging evidence suggests that members of the IGF family, including IGF-1, IGF-2, the IGF-1 receptor (IGF-1R), and the IGF binding proteins (IGFBPs), play important roles in the development and progression of cancer. Both in vitro and in vivo studies show that IGFs are strong mitogens for a variety of cancer cells. IGF-1 also has an antiapoptotic action on cancer. IGF-1R, overexpressed in cancer cells, mediates the effects of IGFs and plays a role in cell transformation induced by tumor virus and oncogene products. IGFBPs inhibit the actions of IGFs and mediate the anti-proliferative effect of wild-type p53 protein, retinoic acid, vitamin D, and transforming growth factor-beta (TGF-beta). Findings from epidemiologic studies support the involvement of IGF in cancer etiology. Diet, nutrition, and other lifestyle features affect the expression and production of IGF-1 and other members of the IGF family. This may provide new approaches for cancer prevention. Growth hormone (GH) stimulates the production of IGF-1. Use of GH replacement therapy to improve physiological and psychological well-being and to prevent aging-related diseases has been recommended. Given the close relationship between GH and IGF-1, the long-term safety of GH treatment warrants a serious concern. If they think that gh is dangerous in the long-term because it increases igf, I wonder if they would flip if they knew people are just using staight igf??

Publication Types:
Review
Review, Academic

PMID: 10234899 [PubMed - indexed for MEDLINE]

This is starting to sound a little troubling. I really want to try it but I'm starting to wonder if its a good idea. Now I struggle with how far should I go in the quest for my goals.

If LA didn't die then that's good enough for me. lol j/k bro.

I will still try it. I haven't seen any research directly linking endogenous supplies of IGF-I to causing cancer. Although there may be one in the future I don't plan to keep my IGF-I levels elevated for a long period of time. (just 4 weeks) If all goes well. I may be on IGF-I for a total of 8 weeks per year (after each cycle for 4 weeks @ 2 cycles per year) for maybe 1-2 years until I reach my goals.

It's quite possibly the same type of research that linked AS usage to prostate, and other cancers, but as we have seen the likely hood of that happening is very minimal for 99.5% of the population.

We are all going to die-It's just how long we take getting there. A lot of us will get cancer. But then so do people who don't juice. I probably won't try it for a while-I would like to see more info published and studied. But I doubt its as bad as eating paint chips.

While thinking this over I started to wonder if a conclusion can be made that the IGF causes cancer, or does cancer somehow cause the IGF, its receptors and binding protein to become more pronounced? (Like the chicken and egg question.) From what I gather, all three, IGF-receptor-binding protein are elevated in the cancer cells. Is there some mechanism that causes this? Does it necessarily follow that exogenous IGF alone would be a cause? The studies didn't really seem to look at the effect of adding IGF-1, just that it is present in elevated amt. in the cancer cells.
Like Biggerstronger said, I'm not planning on using it for an extended time, and not at the dose that a lot of people are using. For me, it still doesn't seem as risky as DNP, or even slin. I plan on trying it if I can.

BiggerStronger said:

I haven't seen any research directly linking endogenous supplies of IGF-I to causing cancer.

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And you won't because IGF-1 does not cause cancer. It never has and it never will. It will, as has already been pointed out, accelerate the growth of malignant cells, thus accelerating the development of the tumor.

Our GH and IGF-1 levels are at their highest during childhood, yet the majority of cancer patients throughout the world are fully developed adults (with endogenous GH levels equivalent to those found in the elderly).

CNBC is rebroadcasting a cancer special Thursday night (6pm ET?)with Maria Bartiromo (sp) that I watched a couple nights ago. It's a roundtable discussion with 5 of the world's top cancer gurus. These guys are seriously heavy hitters in the field. According to current research, cancer develops when a handful of genes goes haywire and creates mutated cells that do not conform to your DNA. The current medication being developed attempts to kill these rogue cells and leave the orderly ones alone (unlike chemo which just kills everything).

I can't recommend this program enough to anyone who is interested in this subject.

goldenear said:

And you won't because IGF-1 does not cause cancer. It never has and it never will. It will, as has already been pointed out, accelerate the growth of malignant cells, thus accelerating the development of the tumor.

Our GH and IGF-1 levels are at their highest during childhood, yet the majority of cancer patients throughout the world are fully developed adults (with endogenous GH levels equivalent to those found in the elderly).

CNBC is rebroadcasting a cancer special Thursday night (6pm ET?)with Maria Bartiromo (sp) that I watched a couple nights ago. It's a roundtable discussion with 5 of the world's top cancer gurus. These guys are seriously heavy hitters in the field. According to current research, cancer develops when a handful of genes goes haywire and creates mutated cells that do not conform to your DNA. The current medication being developed attempts to kill these rogue cells and leave the orderly ones alone (unlike chemo which just kills everything).

I can't recommend this program enough to anyone who is interested in this subject.

Click to expand...

I was just basing the possible cancer causing aspect off of what gymrat said about irradical mitosis within the cells that it's introduced to.

I guess the main concern for most would be the advancement of any damaged cells (tumor/cancer) currently within your body.