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Q: What is transdermal delivery?
Transdermal delivery is a method of delivering active drugs through the skin barrier, and is in many cases superior to other forms of delivery (oral, sublingual, etc). It involves applying active substances (such as prohormones) dissolved in a carrier (a substance or blend of substances designed to promote delivery of the active ingredient past the skin barrier).
Q: Why is transdermal administration of prohormones superior to oral administration?
There are numerous reasons why transdermal delivery can be preferable. The first is that transdermal delivery allows prohormones to avoid first pass metabolism in the liver. Most prohormones are readily destroyed in the digestive tract and liver, often making the dosages required (and money spent) much higher compared to transdermal delivery. It is estimated that transdermal prohormones have a 30-40% absorption rate, compared to 5-15% for oral prohormones. Also, certain hormonal substances may be toxic to the liver, and transdermal delivery significantly lessens this. Secondly, orally delivered prohormones have very short half-lives and must be taken 3-4 times daily. Not only is this inconvenient, but it means that during certain periods (such as sleep) blood levels of the hormone will be very low. Transdermal delivery effectively leads to a steady release over 12 or more hours, solving both of these problems.
Q: What are the advantages and disadvantages of transdermal administration of prohormones when compared to sublingual/nasal administration?
Sublingual (absorption in the mouth, like a lozenge) and nasal delivery is limited by the amount that can be absorbed by the mucous membranes. The maximum amount of hormone that can be delivered is around 25 mg, and blood levels are elevated for 2-3 hours, compared to ~12 for transdermal. Therefore, sublingual and nasal prohormones must be dosed at least 5 times a day to be effective. However, sublingual/nasal delivery delivers 80-90% of the actives to the bloodstream, making it a very efficient carrier. A combination of transdermal application (for steady blood levels) and sublingual/nasal application (to spike blood levels, particularly pre-workout) could be effective.
Q: If I apply a transdermal hormone to a certain muscle group, does it increase strength in that particular muscle group?
Transdermal prohormones are delivered systemically, so applying them to a particular area will not cause disproportionate strength gain in that area. The exception is products that are geared toward local delivery, such as Sytenhance.
Q: Should transdermal prohormones be cycled differently than oral prohormones?
Cycles with transdermal prohormones should be the same length as one would use with oral prohormones, and post-cycle recovery should remain the same. The primary differences are how often you will administer the prohormone (two times daily as opposed to three or four) and the dose used.
Q: What are the dosages for transdermally administered hormones?
First off, it should be noted that the listed dosage and duration on product labels is often conservative. Also, dosage will vary on stacking, level of experience, and many other factors. Here are some general guidelines
1-testosterone : 200-500 mg
19-norandrostenediol: 400-800 mg
4-androstenediol: 400-600 mg
3-alpha androstenediol: 50-150 mg
3-beta androstenediol: 200-500 mg
4-hydroxyandrostenedione (formestane): 50-200 mg
androstenetrione (6-OXO): 150-500 mg
7-OXO-DHEA (7-Keto): 100 mg
Transdermal delivery is a method of delivering active drugs through the skin barrier, and is in many cases superior to other forms of delivery (oral, sublingual, etc). It involves applying active substances (such as prohormones) dissolved in a carrier (a substance or blend of substances designed to promote delivery of the active ingredient past the skin barrier).
Q: Why is transdermal administration of prohormones superior to oral administration?
There are numerous reasons why transdermal delivery can be preferable. The first is that transdermal delivery allows prohormones to avoid first pass metabolism in the liver. Most prohormones are readily destroyed in the digestive tract and liver, often making the dosages required (and money spent) much higher compared to transdermal delivery. It is estimated that transdermal prohormones have a 30-40% absorption rate, compared to 5-15% for oral prohormones. Also, certain hormonal substances may be toxic to the liver, and transdermal delivery significantly lessens this. Secondly, orally delivered prohormones have very short half-lives and must be taken 3-4 times daily. Not only is this inconvenient, but it means that during certain periods (such as sleep) blood levels of the hormone will be very low. Transdermal delivery effectively leads to a steady release over 12 or more hours, solving both of these problems.
Q: What are the advantages and disadvantages of transdermal administration of prohormones when compared to sublingual/nasal administration?
Sublingual (absorption in the mouth, like a lozenge) and nasal delivery is limited by the amount that can be absorbed by the mucous membranes. The maximum amount of hormone that can be delivered is around 25 mg, and blood levels are elevated for 2-3 hours, compared to ~12 for transdermal. Therefore, sublingual and nasal prohormones must be dosed at least 5 times a day to be effective. However, sublingual/nasal delivery delivers 80-90% of the actives to the bloodstream, making it a very efficient carrier. A combination of transdermal application (for steady blood levels) and sublingual/nasal application (to spike blood levels, particularly pre-workout) could be effective.
Q: If I apply a transdermal hormone to a certain muscle group, does it increase strength in that particular muscle group?
Transdermal prohormones are delivered systemically, so applying them to a particular area will not cause disproportionate strength gain in that area. The exception is products that are geared toward local delivery, such as Sytenhance.
Q: Should transdermal prohormones be cycled differently than oral prohormones?
Cycles with transdermal prohormones should be the same length as one would use with oral prohormones, and post-cycle recovery should remain the same. The primary differences are how often you will administer the prohormone (two times daily as opposed to three or four) and the dose used.
Q: What are the dosages for transdermally administered hormones?
First off, it should be noted that the listed dosage and duration on product labels is often conservative. Also, dosage will vary on stacking, level of experience, and many other factors. Here are some general guidelines
1-testosterone : 200-500 mg
19-norandrostenediol: 400-800 mg
4-androstenediol: 400-600 mg
3-alpha androstenediol: 50-150 mg
3-beta androstenediol: 200-500 mg
4-hydroxyandrostenedione (formestane): 50-200 mg
androstenetrione (6-OXO): 150-500 mg
7-OXO-DHEA (7-Keto): 100 mg
