1. #1
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    Default Hyperplasia (Increased Muscle Cells) & Mitogenesis (Growth of New Muscle Fibers)

    IGF-1 Lr3

    What is IGF-1?
    What is IGF-1 Lr3?


    How much IGF-1 Lr3 should be used?
    How long should IGF-1 Lr3 be used?
    See below for the answers to the above questions

    What is IGF-1?
    IGF-1 is a polypeptide hormone about the same size as insulin, or 70 amino acids. Its a highly anabolic hormone released primarily in the liver (but also in peripheral tissues) and stimulates the production of growth hormone. It is responsible for much of the anabolic activity of growth hormone, including nitrogen retention and protein synthesis as well as muscle cell hyperplasia (increase in number of muscle cells), as well as mitogenesis (the growth of new muscle fibers).

    IGF-1 is necessary as well as sufficient in muscle growth (anabolic) and has been shown to also be highly anti-catabolic agent as well. As with all anabolic substances, IGF-1s anabolic effects are still limited only by the protein supply within muscle cells. Thus IGF works much better when enough protein is supplied to the muscle.

    For athletes and bodybuilders who are rehabilitating an injury IGF is vital to the proper production of connective tissue, and studies have shown that exogenous IGF administration may improve collagen formation and aid in the repair of cartilage and would greatly decrease recovery time as well as increase the strength of the recovered area.

    A study examined the injection of insulin-like growth factor I (IGF-I) in different muscle fibers. The researchers concluded that IGF-I promotes an average increase of 15% in muscle mass and a 14% increase in strength in muscle tissue. The researchers have speculated that these effects are primarily due to stimulation of muscle regeneration via the activation of satellite cells by IGF-I.

    A 15% increase in muscle mass, and a 14% increase in strength are no small increases. If we could realistically expect 7% gains in muscle mass and strength (half of the gains experienced in the study), then this would be able to help through plateaus or injuries.

    What is IGF-1 Lr3?
    IGF-1 Lr3 (Insulin-like Growth Factor-I Long R3) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), as well as a 13 amino acid extension peptide at the N-terminus. IGF-I Lr3 is significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins.

    What is a typical protocol for IGF-1 Lr3?
    Studies have suggested the following:
    A typical protocol would be:

    50-100mcg of IGF-1 Lr3 divided into 1-2 bilateral administrations in 2-5 different areas of the muscles approximately 5-7 days a week – intramuscular injections.
    Example, if you want to administer 100mcg of IGF-1 Lr3 into the chest in 2 different areas of the muscle then you would need to divided the dose as follows:
    100mcg per administration / 2 chest muscles = 50mcg per muscle
    50mcg per muscle / 2 different locations on each muscle = 25mcg per injection


    Theoretically, the more locations used to administer the IGF-1 Lr3 into the muscle the more places for muscle growth.

    Studies have also suggested the following:

    Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production.

    Administration should not be given within 2 hours before sleeping in order not to reduce natural growth hormone production.

    After administering, adequate protein needs to be ingested for IGF-1 to be effective in building new muscle.

    How long should IGF-1 Lr3 be used?
    In most studies on IGF-1 Lr3 no adverse side effects were reported with use of 8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

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    Author: Ben Presser
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    MGF (Mechano Growth Factor)

    MGF Questions
    What is MGF (Mechano Growth Factor)?
    How much MGF should be used?
    How long should MGF be used?

    See below for the answers to the above questions
    What is MGF (Mechano Growth Factor)?
    MGF (also known as IGF-1Ec) is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for the growth of adult muscle. MGF is produced naturally when muscle fibers are broken down through resistance (weight training). MGF stimulates muscle growth, creates new muscle fibers, promotes muscle recovery, promotes nitrogen retention and increases protein synthesis.

    In studies where MGF was administered intramuscularly, there was a 20% increase in the weight of the injected muscle fibers within 2 weeks. In further studies, it took 4 months for IGF to cause a 25% increase in muscle mass. MGF was found to be more potent than IGF-1 in rapid muscle growth. Fat loss and strength increases are not typically seen with MGF’s use (as they are with IGF-1 use).
    How much MGF should be used?
    Studies have suggested the following:
    A typical protocol would be:
    100-300mcg of MGF divided into 1-2 bilateral administrations in 2-5 different areas of the muscles approximately 5-7 days a week – intramuscular injections.

    Example, if you want to administer 200mcg of MGF into the chest and biceps muscles 2 times a day and 3 different areas of the muscle then you would need to divided the dose as follows:
    200mcg / 2 times per day = 100mcg per administration
    100mcg per administration / 4 muscles (2 chest and 2 bicep muscles) = 25mcg per muscle
    25mcg per muscle / 3 different locations on each muscle = 8.3mcg per injection

    Theoretically, the more locations used to administer the MGF into the muscle the more places for muscle growth.
    Studies have also suggested the following:
    Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production.

    Administration should not be given within 2 hours before sleeping in order not to reduce natural growth hormone production.
    After administering, adequate protein needs to be ingested for MGF to be effective in building new muscle.
    How to reconstitute MGF?
    MGF is typically manufactured in 2mg amounts and is reconstituted with sterile water.
    - If 2ml (2 full – 1 ml U-100 insulin syringe) of sterile water is added to the vial then each unit of the syringe will equal 10mcg.
    - If the syringe is filled up to 10 units (up to the number 10 on the syringe) it will equal 100mcg of MGF.

    How long should MGF be used?
    In most studies on MGF no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

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    Author: Ben Presser
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    Great info brotha Thanks!
     

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    bumping a great read
    Author: Ben Presser
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    good read to float to the top
    Author: Ben Presser
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    good bump
    Author: Ben Presser
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    Just getting some thoughts. Is anyone following that statement above by staying on for only 8 weeks and then off 4?? It sounds many guys are on it much longer...
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    yeah bro a lot of the articles that are still around list shorter stays on igf, but as the years go by and guys have used it, many and myself included have concluded that the igf-1 lr3 continues to work well for months on end, and the original ideas posed years ago about saturating igf receptors and such was just cautionary, and you can indeed see gains even months into ur use of igf, so thats where a lot for he confusion is, many old articles
    Last edited by Presser; 08-01-2015 at 08:10 AM.
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    Author: Ben Presser
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    Great read bro!!!!
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    SOLID READ!!
    Author: Ben Presser
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    floating a great read
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    Author: Ben Presser
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    Awesome read. I was always scared about desensitizing igf levels due to overuse on igf lr3. Something Palumbo kinda preaches. Hasn't stopped me from using 100mcg ed though! Lol
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    lol, yeah well consider the source bro lol,
    Author: Ben Presser
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    bump a solid read
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    Author: Ben Presser
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    Quote Originally Posted by Presser View Post
    bump a solid read
    ive been reading practically nothing but solid reviews of MC's IGF1LR3. I have all of my AAS in place but have never used that particular product. I know about hyperplasia.

    my question is this: with IGF1LR3 use do you get quality muscle gains overall or is this sort of like a site injection product to bring up weak areas? In other forums I've read about guys pinning their biceps and triceps with the product. I was just curious as to whether or not localized muscle growth is true in the case of this supplement or does it lead to gains overall?

    like I said, really interested in this product and will more than likely be tossing it in my next cycle
     

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    there was a rumor... i think from Victor Martinez .. thats its hard to find REAL Igf1 LR3.... i havent heard that any where else
     

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    Quote Originally Posted by DsgrntldBarbell View Post
    ive been reading practically nothing but solid reviews of MC's IGF1LR3. I have all of my AAS in place but have never used that particular product. I know about hyperplasia.

    my question is this: with IGF1LR3 use do you get quality muscle gains overall or is this sort of like a site injection product to bring up weak areas? In other forums I've read about guys pinning their biceps and triceps with the product. I was just curious as to whether or not localized muscle growth is true in the case of this supplement or does it lead to gains overall?

    like I said, really interested in this product and will more than likely be tossing it in my next cycle
    overall.but its a good idea to use it on the bodypart your training that day if possible
     

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    awesome read for anyone who wants to learn how to maximize their cycles and muscle growth
    Author: Ben Presser
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    "Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production."

    So should it not being taken immediately PWO? The reasoning I was using it PWO was the up-regulation of igf-1 receptors induced by exercise so using it within that window would give a greater chance of it mostly binding within that muscle and less of it going systemic.
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    Professional shit fucker upper

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    Quote Originally Posted by FooterDan View Post
    "Administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production."

    So should it not being taken immediately PWO? The reasoning I was using it PWO was the up-regulation of igf-1 receptors induced by exercise so using it within that window would give a greater chance of it mostly binding within that muscle and less of it going systemic.
    ITS AN OLD ARTICLE, AND I THINK DUE TO NATURAL MGF PRODUCTION POST EXERCISE IT INHIBITS IGF, OR SOME SHIT, I MIGHT HAVE IT WAY OFF LOL, MIGHT NOT BE MGF, BUT SOMEHTING SUPPOSEDLY IS PRODUCED POST WORKOUT THAT INHIBITS IGF, BUT ITS BULLSHIT BRO , NOT THAT IT DOESNT HAPPEN THAT WAY, BUT ITS SO MINIMAL IS DOESNT MAKE A DIFFERENCE IN MY OPINION.

    I WOULD CONTINUE TO DO IT POST WORKOUT TO HELP SHUTTLE /FORCE MORE NUTRIENTS TO THE MUSCLE, SO DO WHAT YOUR DOING IF ITS WORKING, YOU CAN FIND MANY VARIATIONS OF THIS ARTICLE, BY MANY AUTHORS, SO AS WITH ANYTHING, IF ITS WORKING AND NOT BROKEN THEN DONT TRY FIXING IT

    I PERSONALLY TAKE IT PRE WORKOUT ALL THE TIME, BUT I HAVE DONE POST WORKOUT FOR A COUPLE CYCLES, WORKS GREAT EITHER WAY, I PERSONALLY JUST LIKE FORCING ALL THE CARBS ANDPROTIEN INTO THE MUSCLE RIGHT BEFORE TRAINING FOR THE EXPLOSIVE SKIN SPLITTING PUMPS
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    YEAH I JUST REREAD THAT ARTICLE AND THE EXACT PART YOUR TALKING ABOUT AND THEY DONT GIVE A VERY GOOD OR EVEN ACCURATE REASON WHY ITS NOT GOOD POST WORKOUT. THERE IS A REASON, AND ITS SOMEHTING LIKE I SAID ABOVE, BUT AGAIN ITS PRETTY MINIMAL AND ENOUGH GUYS HAVE ACTUAL USER EXPERIENCE WITH IT NOW, THAT WE WOULD KNOW BY NOW IF IT WAS THAT BIG OF A DEAL TAKING IT WITHIN 2 HOURS OF TRAINING
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    Bump for a great read.
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    Why igf-1 lr3 works so well. Fantastic read
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    I reread this every once and a while and get more out of it each time!!
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    bumping a great read
    Author: Ben Presser
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    Quote Originally Posted by Iron-game View Post
    I reread this every once and a while and get more out of it each time!!
    low comprehension levels? Did you get picked up for school on the Short yellow school bus to?

    lmao
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    Yeah why you got to bring that up
     

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    bumping up solid read on growth factors and building muscle
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    some information on igf 1 lr3 that needed to be floated back up
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    Hyperplasia bump
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    Article on why igf-1 specifically lr3 igf-1 should be added to every cycle and even as a stand alone during post cycle therapy.
    Author: Ben Presser
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    Floating this up for the new comers!
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    Great read if you havent read it yet, and your looking into adding some igf-1 lr3 into your next cycle run! It does make all the difference in the world! NO BS!

    Disclaimer: If you flex your abs, and cant see a crease or any ab definition, then IGF 1 lr3 is NOT for you! Not yet anyhow!!!

    Just wanted to make sure that was clear
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    Nice compact reminder.
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    To the top!
    Author: Ben Presser
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    Author: Ben Presser
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    Author: Ben Presser
    Ph.D. P.E.D. Kinesiology
    Intramuscular Injection Certified

    Aromatase Inhibitors, Post Cycle Therapy, Stenabolic, GW, Osta, LGD, S4 and IGF 1 Store

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