DecaDent*
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This study,altough done on rats,demonstrated increased cortisol levels and enlargement of the adrenal glands after 45d of Clen. If the same holds for gymrats,this effect would be counterproductive to adding muscle mass. Comments ??
The effect of clenbuterol on adrenal function in rats.
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The aim of this study was to evaluate whether the administration of clenbuterol causes stressful effects in rats, as reflected by the adrenal function. Anabolic doses of clenbuterol (1 mg kg-1, 99% purity) were administered orally by stomach tube daily for 45 d to female Long . Hormonal levels of cortisol and corticosterone, and histopathological analysis, were used as indicators of the adrenal function. Increased corticosterone and cortisol secretion was found in the treated group (p < 0.001), both in adrenal homogenates and peripheral blood samples, compared with control animals. Higher relative adrenal gland weight (adrenal gland-to-body weight ratio) was also found in the treated group (p < 0.01). The major histopathological finding was the presence of hyperplasia in the adrenocortical cells.
It was concluded that the administration of an anabolic dose of clenbuterol causes a hyperstimulation of adrenal gland secretion that could adversely affect animal welfare.
Analyst 1998 Dec;123(12):2521-4 (ISSN: 0003-2654)
Illera JC; Silvan G; Blass A; Martinez MM; Illera M
Departamento de Fisiologia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain
The effect of clenbuterol on adrenal function in rats.
.
The aim of this study was to evaluate whether the administration of clenbuterol causes stressful effects in rats, as reflected by the adrenal function. Anabolic doses of clenbuterol (1 mg kg-1, 99% purity) were administered orally by stomach tube daily for 45 d to female Long . Hormonal levels of cortisol and corticosterone, and histopathological analysis, were used as indicators of the adrenal function. Increased corticosterone and cortisol secretion was found in the treated group (p < 0.001), both in adrenal homogenates and peripheral blood samples, compared with control animals. Higher relative adrenal gland weight (adrenal gland-to-body weight ratio) was also found in the treated group (p < 0.01). The major histopathological finding was the presence of hyperplasia in the adrenocortical cells.
It was concluded that the administration of an anabolic dose of clenbuterol causes a hyperstimulation of adrenal gland secretion that could adversely affect animal welfare.
Analyst 1998 Dec;123(12):2521-4 (ISSN: 0003-2654)
Illera JC; Silvan G; Blass A; Martinez MM; Illera M
Departamento de Fisiologia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain