There's an article over on bodybuilding.com by Derek Cornelius that mentions glycocyamine being used to convert to creatine in the liver for non-creatine responders, but that you must also supplement with betaine in a 4:1 ratio to keep the liver supplied with methyl groups or the glycocyamine will increase homocysteine and cause damage, etc. He recommends always having a 4:1 ratio of betaine to glycocyamine in any product using glycocyamine.