"Myostatin Blockers Destroy Tendons"

[the4mandrummer]

Just found an interesting article about a possible negative side effect of blocking myostatin.

http://www.ergo-log.com/myostatintendons.html

""Those interested in myostatin inhibitors need to be aware of the fact that by doing these things to muscles, they may be having negative effects on tendons", warns research leader John Faulkner. The researchers suspect that muscles manufacture myostatin for a reason: it appears to strengthen the tendons. "

Keep in mind that this test was conducted on mice with defective myostatin genes, not mice that had been administered myostatin blockers.

Maybe cycling myostatin blockers would prevent this? How long until the lack of myostatin causes the breakdown of tendons?

What do you guys think?

 

[Pharm_Fed]

That is an interesting aspect I haven't heard come up before. Hopefully with these products starting to gain popularity there will be a lot more research soon.

 

[saudades]

I think that they will try to use this as an excuse to delay release of any myostatin blocking compounds to the public. The tests themselves show that a complete absence of myostatin via gene modification will cause the weakened tendons, however, it seems clear (at least to me) that in an adult human that may only be blocking a small percentage to speed up muscle growth, there may only be minimal weakening of tendons which could then be reversed after cycling off of the myostatin blocker. I think it would be obvious that you would not want such a large dosage that you increase your mass by more than 50% in only two weeks since it would be extremely hard on your body so the best route would be to increase mass gradually by cycling on and off. For the most part, we bodybuilders aren't stupid though a lot of the media and medical community seem to think we are.

I doubt that there would be any more weakening of the tendons than there would be when using AAS which are also known to cause problems with tendons either through direct weakening or through the indirect effect that the tendons don't keep up with the muscle growth. Having used MYO-029 for a week, I didn't experience any adverse effects in my tendons that I can tell by feel, and now that I'm off of it, my tendons are certainly free to be strengthened so that would tend to support my theory.

 

[the4mandrummer]

Yeah that's what I was thinking: that cycling relatively low doses would negate the negatives.

Glad to see that you didn't notice anything while on the stuff.

thanks for the replies!

 

[h8tr3d]

AAS weakens tendons too. Ask any Doctor

 

[Presser]

AAS weakens tendons too. Ask any Doctor

yep!

 

[bigheinz]

What i hear from a good source it is because the muscles grow too fast and the tendons doesnt have the ability to stretch as fast so you might get injure. He recommend to train light or moderate weights until your body and ligaments adapts to the drastic muscle growth

 

[h8tr3d]

What i hear from a good source it is because the muscles grow too fast and the tendons doesnt have the ability to stretch as fast so you might get injure. He recommend to train light or moderate weights until your body and ligaments adapts to the drastic muscle growth

yeah that makes sense. I wonder how fast you would actually start seeing changes in your body? days, weeks, months??

 

[saudades]

^ ^ ^ It would be dependent on the dose, but in the case of a large enough dose of ACVR2B or ACE-031, you would grow within a matter of 2-3 weeks. The larger the dose, the more growth that would occur in that time period. For example, 4.5 grams of ACVR2B would take me from 210 to literally 330 lbs in two weeks (a 60% increase). That is like right out of a sci-fi movie kind of growth. You would literally wake up bigger each morning or be able to see your body expanding during the day (it would be about 9 lbs per day in my example). Man, it makes my mind race to think about it.

 

[Pharm_Fed]

^ ^ ^ It would be dependent on the dose, but in the case of a large enough dose of ACVR2B or ACE-031, you would grow within a matter of 2-3 weeks. The larger the dose, the more growth that would occur in that time period. For example, 4.5 grams of ACVR2B would take me from 210 to literally 330 lbs in two weeks (a 60% increase). That is like right out of a sci-fi movie kind of growth. You would literally wake up bigger each morning or be able to see your body expanding during the day (it would be about 9 lbs per day in my example). Man, it makes my mind race to think about it.

That is pretty crazy to think about.

 

[dreww]

^ ^ ^ It would be dependent on the dose, but in the case of a large enough dose of ACVR2B or ACE-031, you would grow within a matter of 2-3 weeks. The larger the dose, the more growth that would occur in that time period. For example, 4.5 grams of ACVR2B would take me from 210 to literally 330 lbs in two weeks (a 60% increase). That is like right out of a sci-fi movie kind of growth. You would literally wake up bigger each morning or be able to see your body expanding during the day (it would be about 9 lbs per day in my example). Man, it makes my mind race to think about it.

where did you come up with those numbers?
and talk about stretch marks!

btw, how is this stuff administered? injections?