hereonearth
New member
I posted a couple days ago asking about Free testosterone. So I've been researching a lot lately on how to boost free test. And I came across this vegetable derivative. (known as DIM).
I'll post some of what I found interesting from my searches:
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[h=1]3,3'-Diindolylmethane (DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. Our results indicate that DIM exhibits potent antiproliferative and antiandrogenic properties in androgen-dependent human prostate cancer cells. DIM suppresses cell proliferation of LNCaP cells and inhibits dihydrotestosterone (DHT) stimulation of DNA synthesis. These activities were not produced in androgen-independent PC-3 cells. Moreover, DIM inhibited endogenous PSA transcription and reduced intracellular and secreted PSA protein levels induced by DHT in LNCaP cells. Also, DIM inhibited, in a concentration-dependent manner, the DHT-induced expression of a prostate-specific antigen promoter-regulated reporter gene construct in transiently transfected LNCaP cells. Similar effects of DIM were observed in PC-3 cells only when these cells were co-transfected with a wild-type androgen receptor expression plasmid. Using fluorescence imaging with green fluorescent protein androgen receptor and Western blot analysis, we demonstrated that DIM inhibited androgen-induced androgen receptor (AR) translocation into the nucleus. Results of receptor binding assays indicated further that DIM is a strong competitive inhibitor of DHT binding to the AR. Results of structural modeling studies showed that DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, although the atomic compositions of the two substances are quite different. Taken together with our published reports of the estrogen agonist activities of DIM, the present results establish DIM as a unique bifunctional hormone disrupter. To our knowledge, DIM is the first example of a pure androgen receptor antagonist from plants.
taken from Plant-derived 3,3'-Diindolylmethane is a strong ... [J Biol Chem. 2003] - PubMed - NCBI
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"In men, diminished estrogen metabolism and estrogen accumulation are central problems associated with aging. DIM strongly promotes its own metabolism and in doing so increases a more active and beneficial metabolism of estrogen. This estrogen metabolism is better because it converts estradiol health promoting 2-hydoxy metabolites. These metabolites help free testosterone from its binding protein for greater testosterone activity and can reduce testosterone and estrogen stimulation of the prostate gland. Together with a healthy diet and exercise, the metabolic shift from DIM results in a "younger" balance of testosterone to estrogen. DIM supplementation is compatible with natural testosterone replacement. DIM works very well for maintaining and increasing healthy testosterone levels."
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THoughts? Anyone tried this?
[/h]
I'll post some of what I found interesting from my searches:
-
[h=1]3,3'-Diindolylmethane (DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. Our results indicate that DIM exhibits potent antiproliferative and antiandrogenic properties in androgen-dependent human prostate cancer cells. DIM suppresses cell proliferation of LNCaP cells and inhibits dihydrotestosterone (DHT) stimulation of DNA synthesis. These activities were not produced in androgen-independent PC-3 cells. Moreover, DIM inhibited endogenous PSA transcription and reduced intracellular and secreted PSA protein levels induced by DHT in LNCaP cells. Also, DIM inhibited, in a concentration-dependent manner, the DHT-induced expression of a prostate-specific antigen promoter-regulated reporter gene construct in transiently transfected LNCaP cells. Similar effects of DIM were observed in PC-3 cells only when these cells were co-transfected with a wild-type androgen receptor expression plasmid. Using fluorescence imaging with green fluorescent protein androgen receptor and Western blot analysis, we demonstrated that DIM inhibited androgen-induced androgen receptor (AR) translocation into the nucleus. Results of receptor binding assays indicated further that DIM is a strong competitive inhibitor of DHT binding to the AR. Results of structural modeling studies showed that DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, although the atomic compositions of the two substances are quite different. Taken together with our published reports of the estrogen agonist activities of DIM, the present results establish DIM as a unique bifunctional hormone disrupter. To our knowledge, DIM is the first example of a pure androgen receptor antagonist from plants.
taken from Plant-derived 3,3'-Diindolylmethane is a strong ... [J Biol Chem. 2003] - PubMed - NCBI
-
"In men, diminished estrogen metabolism and estrogen accumulation are central problems associated with aging. DIM strongly promotes its own metabolism and in doing so increases a more active and beneficial metabolism of estrogen. This estrogen metabolism is better because it converts estradiol health promoting 2-hydoxy metabolites. These metabolites help free testosterone from its binding protein for greater testosterone activity and can reduce testosterone and estrogen stimulation of the prostate gland. Together with a healthy diet and exercise, the metabolic shift from DIM results in a "younger" balance of testosterone to estrogen. DIM supplementation is compatible with natural testosterone replacement. DIM works very well for maintaining and increasing healthy testosterone levels."
-
THoughts? Anyone tried this?
[/h]
