Can they give unwanted sides to the user, sure they can. Are they safe, IMHO YES. There no worse than tylenol which has killed countless amounts of ppl from taking to much not to mention wear out the lining of the stomach, and cause many other sides.
DW hit it on the head, women have ot take thses supps in much lower doseages than men b/c they are much more sensitive to the supp's.
I take it body2see, you must be completely natty then right??? Cause most supps affct the body in one way or another and have some unwanted sides.