The liver converts HGH to IGF-1, but HGH does allot more then just produce IGF-1. The reason why IGF-1 looses its effectiveness is not known at this time, their are several theorys. One of them suspects that the body may form antibodys to the IGF-1 (doubtfull and no evidence). Another one belives that natural IGF-1 production maybe be lowered after weeks of foreign IGF-1 useage. Their is one or two more that I don't recall.
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