IGF

[goldenear]

I guess the main concern for most would be the advancement of any damaged cells (tumor/cancer) currently within your body.

You bet that's a concern! And it should be a concern for every AAS user as well because of the growth-promoting environment created by the drugs.

 

[Harvey Balboner]

good info, nice to finally see some possible sides listed

 

[LA]

Everyone should go back to that 1st long IGF post that contained everything anyone could fine on the web and re-read the whole thing!

Sides are the same as with GH and Slin!

Bad GH sides include- bone growth and existing cancer cells growing!

Slin sides include- hypo, which can lead to coma and death!

The bad sides of GH and Slin (which I'm aware of) that does not transfer over to IGF is fat accumulation and insulin resistance.

It is very possible that nearly all of the benes of GH come from the conversion to IGF. However, there seems to be an upper limit to how much GH will convert to IGF. By using IGF instead of GH you get around that upper limit. Something else to think about. You are really trending in uncharter territory.

 

[josh]

isnt that why dave palumbo recommends no more than 3-4 iu gh per day b/c it will only convert so much igf. anymore would just be a waste.

 

[bigshug]

Once again, the amount of knowledge on this board is astounding........

I'd like to see more along the notion that erratic cellular mitosis could be a possible cancer cause - makes total sense, especially considering the accelerated rate at which cells would actually be dividing

 

[rippedchef]

Man do I feel like a stupid cook-way too many very intelligent bros here-I'm gonna go read to my kids-at least a 4 and 9 yr old think I'm smart!!LOL-Thanks to all the bros who consistently take the time to post studies and explain issues-greatly appreciated!!

 

[machine99]

I haven't seen any research directly linking endogenous supplies of IGF-I to causing cancer. Although there may be one in the future I don't plan to keep my IGF-I levels elevated for a long period of time. (just 4 weeks)

J Clin Endocrinol Metab. 1996 Aug;81(8):2968-75.

At 3 weeks, the treatment group combination recombinant human GH (rhGH; Nutropin; 0.34 mg, sc, twice daily) and rhIGF-I (5.0 mg, sc, twice daily) had a significantly larger weight increase (P = 0.0003), but this difference was not observed at any later time point.

PMID: 8768860 [PubMed - indexed for MEDLINE]

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Exerc Sport Sci Rev. 1994;22:285-312. Related Articles, Links


Growth hormone effects on metabolism, body composition, muscle mass, and strength.

Yarasheski KE.

Metabolism Division, Washington University School of Medicine, St. Louis, Missouri.

It is clear that the anthropometric ramifications, especially with respect to muscle mass, of the metabolic actions of GH and IGF-I treatment in intact and GH-deficient adults require further study. At present, it appears that daily GH or IGF-I treatment modestly increases nitrogen retention in most normal adults, probably by separate but permissive mechanisms, but only for a short period of time (approximately 1 month).

Though some researchers seem to miss this point(since in this first study they said igf/gh weren't effective for muscle wasting - 12 weeks of continual usage using rhIGF instead of Long r3 IGF), after 3-4 weeks igf seems to be pretty ineffective.

As far as igf and its relationship with cancer, I think so far it has only been shown to speed up your current cancer cell activity, not cause normal cells to turn cancerous so I'm not worried about it. When using these drugs we should all understand that there are health risks and I love this board because the side effects of drugs are discussed just as often as the benefits around here.

 

[Badgermoon]

J Clin Endocrinol Metab. 1996 Aug;81(8):2968-75.

At 3 weeks, the treatment group combination recombinant human GH (rhGH; Nutropin; 0.34 mg, sc, twice daily) and rhIGF-I (5.0 mg, sc, twice daily) had a significantly larger weight increase (P = 0.0003), but this difference was not observed at any later time point.

PMID: 8768860 [PubMed - indexed for MEDLINE]

I must be reading something wrong...does it say that they were giving subjects 5mg/2xday of IGF?

 

[Harvey Balboner]

good info

that's the way it reads to me to badger, doesn't sound right