Question about injecting methylated orals suspended in gso

I can't take methylated orals due to gallbladder/liver issues. Plus I am an older guy. If I inject a methylated oral powder suspended in GSO, am I still going to have to deal with the liver issues due to the methylated compound?

It just makes one pass through when injected as opposed to two when taken orally , at least that's what I've always thought , so theirs less stress on ur liver but that compounds still pretty harsh either way I think

Ehhh... Once or twice the real problem isn't the passes its the "methylated" connecting atom that causes the problems... Your liver actually has to break and absorb that methyl group (first pass) in order for the compound to "break" and become active and absorbed... and then these "new compounds" go through a second pass for detox purposes. I am not sure that injecting a methylated compound would negate a second pass as alkaloid AAS still require a double pass too (I know most people think it's only methylated PH that require double passes lol (someone correct me if I am wrong on this one as I've only seen two studies on this)) ... I would not recommend taking a methyled compund with your gallbladder/liver issues. theres so many things out there you can stick yourself with that won't be so hard on the liver... again In my opinion... you will not reduce the potential hepa-toxic sides by injecting methyl groups...

Yoda is pretty much on point with his statement... The only thing I'll add to that, is that when taken by injection, the compound is filtered at a lower rate, through the liver(thus slightly lowering hepatotoxicity from a bolus dose.... But the same amount of compound still has to be metabolized by the liver, just at a different rate than orally). Also, to clear up yoda interpretation of liver metabolism, ph are metabolized by liver in the same ways as aas. There is extensive metabolization by the liver, and by other organs/tissues... It's more than a 'one pass' or 'two pass' type of system... Either way, it's very similar for both ph and aas...

overburdened said:

Yoda is pretty much on point with his statement... The only thing I'll add to that, is that when taken by injection, the compound is filtered at a lower rate, through the liver(thus slightly lowering hepatotoxicity from a bolus dose.... But the same amount of compound still has to be metabolized by the liver, just at a different rate than orally). Also, to clear up yoda interpretation of liver metabolism, ph are metabolized by liver in the same ways as aas. There is extensive metabolization by the liver, and by other organs/tissues... It's more than a 'one pass' or 'two pass' type of system... Either way, it's very similar for both ph and aas...

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Exactly what I was saying... but I said while watching Labron James shove the ball down the pacers throat! Just saying... The Heat won... you forgot that point lol

No really though OB... Basically what I understand minus the reduced hepatoxicity... Just because it metabolized slower... doesn't make it less toxic in all reality does it... amount over time = hepatoxic... not amount at once right... given there is extremes that would make the second statement true but... generally speaking and considering all use is being done intelligently... isn't is amount over time and not amount per use that determines toxicity?

Yes, basically that is true... There is small variances in HIGHLY toxic substances, that make them SLIGHTLY more tolerable, for very short periods of time(methyltren is what comes to mind for an example of this... It's highly toxic, yet is tolerated for VERY short runs, at a dose roughly 3x higher than what could be tolerated orally... 1.5mg/day for 2 weeks vs 500mcg/day at two weeks...). That is an example that I can think of as an exception to the rule... But that's what it is, is an exception... Methyltren is actually used by researchers to cause liver failure in rats... Part of it's action is due to the bolus dose(all at once) hitting the liver...

overburdened said:

Yes, basically that is true... There is small variances in HIGHLY toxic substances, that make them SLIGHTLY more tolerable, for very short periods of time(methyltren is what comes to mind for an example of this... It's highly toxic, yet is tolerated for VERY short runs, at a dose roughly 3x higher than what could be tolerated orally... 1.5mg/day for 2 weeks vs 500mcg/day at two weeks...). That is an example that I can think of as an exception to the rule... But that's what it is, is an exception... Methyltren is actually used by researchers to cause liver failure in rats... Part of it's action is due to the bolus dose(all at once) hitting the liver...

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That would be my problem with this report as well as the Arginine one... They are realistically impossible circumstances... 10grams all at once on a rats pancrease will piss it off I am sure lol 3 grames of methyl compounds on a liver all at once in a rat will piss its liver off too... those aren't realistic real world applications... at the same time it's rats... we are much more resilient then they are. I am by no means taking away from what your saying, we both are saying the same thing about this thread, but I'd like to see it more based off of human consumption and studies verses bolus doses in rats... this little tangent probably would have fit better in the Arginine thread... I'm just saying bolus doses in rats doesn't equal intelligent use by humans.

Thank you so much Yoda and Overburdened for your contribution to this thread. You guys rock. Lots of smart people here on MC.

Yoda said:

That would be my problem with this report as well as the Arginine one... They are realistically impossible circumstances... 10grams all at once on a rats pancrease will piss it off I am sure lol 3 grames of methyl compounds on a liver all at once in a rat will piss its liver off too... those aren't realistic real world applications... at the same time it's rats... we are much more resilient then they are. I am by no means taking away from what your saying, we both are saying the same thing about this thread, but I'd like to see it more based off of human consumption and studies verses bolus doses in rats... this little tangent probably would have fit better in the Arginine thread... I'm just saying bolus doses in rats doesn't equal intelligent use by humans.

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You are 100% correct! I don't think any of us would use these things the way theyare uused in labs.