Deposterona (testosterone blend) anabolic steroid profie and use in bodybuilding

akn · Jun 13, 2014

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Deposterona is an injectable veterinary steroid preparation
that contains a blend of three different testosterone esters.
Each milliliter contains 12mg of testosterone acetate, 12mg
of testosterone valerate, and 36mg of testosterone
undecanoate, for a total steroid concentration of 60 mg/mL.
This is currently the only commercial steroid product
available that contains testosterone valerate, which is a short
to medium acting ester with a half-life approximately double
that of testosterone propionate.455 With its blend of slowand
fast-acting esters, Deposterona is essentially a low
dosed alternative to Sustanon, although given the use of
testosterone undecanoate it will be longer acting with more
unbalanced pharmacokinetics.
History:
Deposterona was developed by Syntex Animal Health
Company several decades ago, and has been sold on the
Mexican veterinary drug market since. It is used primarily to
treat impotence, weakness, fatigue, and hypogonadism in
male breeding animals (cows, pigs, canines, and sheep), and
also as a general protein-sparing anabolic. Deposterona is
now sold under the Fort Dodge Animal Health label, which
acquired Syntex Animal Health in the mid-1990’s.
How Supplied:
Deposterona is available on the Mexican veterinary drug
market.It contains 12mg of testosterone acetate, 12mg of
testosterone valerate, and 36mg of testosterone undecanoate
per milliliter of oil; packaged in a 10 mL multi-dose
vial.Twelve vials are packed in each box.
Structural Characteristics:
Deposterona contains a mixture of three testosterone
compounds, which where modified with the addition of
carboxylic acid esters (acetic, valeric, and undecanoic
acids) at the 17-beta hydroxyl group. Esterified forms of
testosterone are less polar than free testosterone, and are
absorbed more slowly from the area of injection. Once in the
bloodstream, the ester is removed to yield free (active)
testosterone. Esterified forms of testosterone are designed to
prolong the window of therapeutic effect following
administration, allowing for a less frequent injection
schedule compared to injections of free (unesterified)
steroid.
Side Effects (Estrogenic):
Testosterone is readily aromatized in the body to estradiol
(estrogen). The aromatase (estrogen synthetase) enzyme is
responsible for this metabolism of testosterone. Elevated
estrogen levels can cause side effects such as increased
water retention, body fat gain, and gynecomastia.
Testosterone is considered a moderately estrogenic steroid.
An anti-estrogen such as clomiphene citrate or tamoxifen
citrate may be necessary to prevent estrogenic side effects.
One may alternately use an aromatase inhibitor like
Arimidex® (anastrozole), which more efficiently controls
estrogen by preventing its synthesis. Aromatase inhibitors
can be quite expensive in comparison to anti-estrogens,
however, and may also have negative effects on blood lipi
Estrogenic side effects will occur in a dose-dependant
manner, with higher doses (above normal therapeutic levels)
of testosterone more likely to require the concurrent use of an
anti-estrogen or aromatase inhibitor. Since water retention
and loss of muscle definition are common with higher doses
of testosterone, this drug is usually considered a poor choice
for dieting or cutting phases of training. Its moderate
estrogenicity makes it more ideal for bulking phases, where
the added water retention will support raw strength and
muscle size, and help foster a stronger anabolic environment.
Side Effects (Androgenic):
Testosterone is the primary male androgen, responsible for
maintaining secondary male sexual characteristics. Elevated
levels of testosterone are likely to produce androgenic side
effects including oily skin, acne, and body/facial hair growth.
Men with a genetic predisposition for hair loss (androgenetic
alopecia) may notice accelerated male pattern balding.
Those concerned about hair loss may find a more
comfortable option in nandrolone decanoate, which is a
comparably less androgenic steroid. Women are warned of
the potential virilizing effects of anabolic/androgenic
steroids, especially with a strong androgen such as
testosterone. These may include deepening of the voice,
menstrual irregularities, changes in skin texture, facial hair
growth, and clitoral enlargement.
In androgen-responsive target tissues such as the skin, scalp,
and prostate, the high relative androgenicity of testosterone is
dependant on its reduction to dihydrotestosterone (DHT).
The 5-alpha reductase enzyme is responsible for this
metabolism of testosterone. The concurrent use of a 5-alpha
reductase inhibitor such as finasteride or dutasteride will
interfere with site-specific potentiation of testosterone
action, lowering the tendency of testosterone drugs to
produce androgenic side effects. It is important to remember
that anabolic and androgenic effects are both mediated via
the cytosolic androgen receptor. Complete separation of
testosterone’s anabolic and androgenic properties is not
possible, even with total 5-alpha reductase inhibition.
Side Effects (Hepatotoxicity):
Testosterone does not have hepatotoxic effects; liver toxicity
is unlikely. One study examined the potential for
hepatotoxicity with high doses of testosterone by
administering 400 mg of the hormone per day (2,800 mg per
week) to a group of male subjects. The steroid was taken
orally so that higher peak concentrations would be reached in
hepatic tissues compared to intramuscular injections. The
hormone was given daily for 20 days, and produced no
significant changes in liver enzyme values including serum
albumin, bilirubin, alanine-amino-transferase, and alkaline
phosphatases.456
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Anabolic/androgenic steroids may also adversely affect
blood pressure and triglycerides, reduce endothelial
relaxation, and support left ventricular hypertrophy, all
potentially increasing the risk of cardiovascular disease and
myocardial infarction.
Testosterone tends to have a much less dramatic impact on
cardiovascular risk factors than synthetic steroids. This is
due in part to its openness to metabolism by the liver, which
allows it to have less effect on the hepatic management of
cholesterol. The aromatization of testosterone to estradiol
also helps to mitigate the negative effects of androgens on
serum lipids. In one study, 280 mg per week of testosterone
ester (enanthate) had a slight but not statistically significant
effect on HDL cholesterol after 12 weeks, but when taken
with an aromatase inhibitor a strong (25%) decrease was
seen.457 Studies using 300 mg of testosterone ester
(enanthate) per week for 20 weeks without an aromatase
inhibitor demonstrated only a 13% decrease in HDL
cholesterol, while at 600 mg the reduction reached 21%.458
The negative impact of aromatase inhibition should be taken
into consideration before such drug is added to testosterone
therapy.
Due to the positive influence of estrogen on serum lipids,
tamoxifen citrate or clomiphene citrate are preferred to
aromatase inhibitors for those concerned with cardiovascular
health, as they offer a partial estrogenic effect in the liver.
This allows them to potentially improve lipid profiles and
offset some of the negative effects of androgens. With doses
of 600 mg or less per week, the impact on lipid profile tends
to be noticeable but not dramatic, making an anti-estrogen
(for cardioprotective purposes) perhaps unnecessary. Doses
of 600 mg or less per week have also failed to produce
statistically significant changes in LDL/VLDL cholesterol,
triglycerides, apolipoprotein B/C-III, C-reactive protein, and
insulin sensitivity, all indicating a relatively weak impact on
cardiovascular risk factors.459 When used in moderate doses,
injectable testosterone esters are usually considered to be the
safest of all anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration.
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. Testosterone is the
primary male androgen, and offers strong negative feedback
on endogenous testosterone production. Testosterone-based
drugs will, likewise, have a strong effect on the hypothalamic
regulation of natural steroid hormones. Without the
intervention of testosterone-stimulating substances,
testosterone levels should return to normal within 1-4 months
of drug secession. Note that prolonged hypogonadotrophic
hypogonadism can develop secondary to steroid abuse,
necessitating medical intervention.
Administration (Men):
For bodybuilding purposes, Deposterona is usually injected
on at least a weekly basis, in a dosage of 120-360 mg (2-6
ml). Dividing the weekly dosage into two or more smaller
applications can reduce injection volume. Cycles are
generally between 6 and 12 weeks in length. This level is
sufficient to provide noticeable gains in muscle size and
strength. Testosterone drugs are ultimately very versatile,
and can be combined with many other anabolic/androgenic
steroids depending on the desired effect.
Administration (Women):
Deposterona is not recommended for women for
performance-enhancing purposes due to its strong androgenic
nature, tendency to produce virilizing side effects, and slowacting
characteristics (making blood levels difficult to
control).
Availability:
Deposterona is only known to be manufactured in Mexico.
Because it contains such a low concentration of steroid,this
product is not in high demand, and not readily diverted for
illicit sale.

Presser · Jun 13, 2014

thats a new one to me brutha…testosterone valerate

akn · Jun 13, 2014

same here lo

Deposterona (testosterone blend) anabolic steroid profie and use in bodybuilding

akn

Musclechemistry Member

Presser

Admin

akn

Musclechemistry Member

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