Testolent (testosterone phenylpropionate) anabolic steroid profile and dosage

akn · Jun 15, 2014

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Testolent is an injectable testosterone preparation containing
the fast-acting phenylpropionate ester of testosterone.
Testosterone phenylpropionate is one of the constituents in
Sustanon®, although this profile concerns its use as a standalone
ingredient. The activity of Testolent is ultimately very
similar to testosterone propionate, supplying the same
hormone over at best a slightly longer duration of release.
While propionate is injected every second or third day,
phenylpropionate might be stretched out to every fourth day.
Testolent might be more comfortable to use, as testosterone
propionate is notoriously very painful at the site of injection,
but otherwise there is really no strong advantage to this

preparation in comparison.
History:
Testosterone phenylpropionate was first described in a
French medical journal in 1955.595 A few isolated
commercial products containing testosterone
phenylpropionate were developed in the years following,
although this never was a popular item. Testolent was the
most recent preparation of testosterone phenylpropionate
known to be on the global steroid market, and was marketed
in Romania by Sicomed. This agent was used primarily to
correct low androgen levels in males, but as also
occasionally prescribed in females for the treatment of
advanced breast cancer, osteoporosis, uterine neoplasm, and
low sex drive. Sicomed recently discounted its sale,
however, and no other products containing only testosterone
phenylpropionate are currently known to exist.
How Supplied:
Testosterone phenylpropionate is no longer available as a
stand-alone commercial drug product. When produced in
Romania, the Testolent brand contained 100 mg of
testosterone phenylpropionate in a 1-milliliter ampule.
Structural Characteristics:
Testosterone phenylpropionate is a modified form of
testosterone, where a carboxylic acid ester (propionic acid
phenyl ester) has been attached to the 17-beta hydroxyl
group. Esterified forms of testosterone are less polar than
free testosterone, and are absorbed more slowly from the
area of injection. Once in the bloodstream, the ester is
removed to yield free (active) testosterone. Esterified forms
of testosterone are designed to prolong the window of
therapeutic effect following administration, allowing for a
less frequent injection schedule compared to injections of
free (unesterified) steroid.
Side Effects (Estrogenic):
Testosterone is readily aromatized in the body to estradiol
(estrogen). The aromatase (estrogen synthetase) enzyme is
responsible for this metabolism of testosterone. Elevated
estrogen levels can cause side effects such as increased
water retention, body fat gain, and gynecomastia.
Testosterone is considered a moderately estrogenic steroid.
An anti-estrogen such as clomiphene citrate or tamoxifen
citrate may be necessary to prevent estrogenic side effects.
One may alternately use an aromatase inhibitor like
Arimidex® (anastrozole), which more efficiently controls
estrogen by preventing its synthesis. Aromatase inhibitors
can be quite expensive in comparison to anti-estrogens
however, and may also have negative effects on blood lipids.
Estrogenic side effects will occur in a dose-dependant
manner, with higher doses (above normal therapeutic levels)
of testosterone more likely to require the concurrent use of an
anti-estrogen or aromatase inhibitor. Since water retention
and loss of muscle definition are common with higher doses
of testosterone, this drug is usually considered a poor choice
for dieting or cutting phases of training. Its moderate
estrogenicity makes it more ideal for bulking phases, where
the added water retention will support raw strength and
muscle size, and help foster a stronger anabolic environment.
Side Effects (Androgenic):
Testosterone is the primary male androgen, responsible for
maintaining secondary male sexual characteristics. Elevated
levels of testosterone are likely to produce androgenic side
effects including oily skin, acne, and body/facial hair growth.
Men with a genetic predisposition for hair loss (androgenetic
alopecia) may notice accelerated male pattern balding.
Those concerned about hair loss may find a more
comfortable option in nandrolone decanoate, which is a
comparably less androgenic steroid. Women are warned of
the potential virilizing effects of anabolic/androgenic
steroids, especially with a strong androgen such as
testosterone. These may include deepening of the voice,
menstrual irregularities, changes in skin texture, facial hair
growth, and clitoral enlargement.
In androgen-responsive target tissues such as the skin, scalp,
and prostate, the high relative androgenicity of testosterone is
dependant on its reduction to dihydrotestosterone (DHT).
The 5-alpha reductase enzyme is responsible for this
metabolism of testosterone. The concurrent use of a 5-alpha
reductase inhibitor such as finasteride or dutasteride will
interfere with site-specific potentiation of testosterone
action, lowering the tendency of testosterone drugs to
produce androgenic side effects. It is important to remember
that anabolic and androgenic effects are both mediated via
the cytosolic androgen receptor. Complete separation of
testosterone’s anabolic and androgenic properties is not
possible, even with total 5-alpha reductase inhibition.
Side Effects (Hepatotoxicity):
Testosterone does not have hepatotoxic effects; liver toxicity
is unlikely. One study examined the potential for
hepatotoxicity with high doses of testosterone by
administering 400 mg of the hormone per day (2,800 mg per
week) to a group of male subjects. The steroid was taken
orally so that higher peak concentrations would be reached in
hepatic tissues compared to intramuscular injections. The
hormone was given daily for 20 days, and produced no
significant changes in liver enzyme values including serum
albumin, bilirubin, alanine-amino-transferase, and alkaline
phosphatases.596
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Anabolic/androgenic steroids may also adversely affect
blood pressure and triglycerides, reduce endothelial
relaxation, and support left ventricular hypertrophy, all
potentially increasing the risk of cardiovascular disease and
myocardial infarction.
Testosterone tends to have a much less dramatic impact on
cardiovascular risk factors than synthetic steroids. This is
due in part to its openness to metabolism by the liver, which
allows it to have less effect on the hepatic management of
cholesterol. The aromatization of testosterone to estradiol
also helps to mitigate the negative effects of androgens on
serum lipids. In one study, 280 mg per week of testosterone
ester (enanthate) had a slight but not statistically significant
effect on HDL cholesterol after 12 weeks, but when taken
with an aromatase inhibitor a strong (25%) decrease was
seen.597 Studies using 300 mg of testosterone ester
(enanthate) per week for 20 weeks without an aromatase
inhibitor demonstrated only a 13% decrease in HDL
cholesterol, while at 600 mg the reduction reached 21%.598
The negative impact of aromatase inhibition should be taken
into consideration before such drug is added to testosterone
therapy.
Due to the positive influence of estrogen on serum lipids,
tamoxifen citrate or clomiphene citrate are preferred to
aromatase inhibitors for those concerned with cardiovascular
health, as they offer a partial estrogenic effect in the liver.
This allows them to potentially improve lipid profiles and
offset some of the negative effects of androgens. With doses
of 600 mg or less per week, the impact on lipid profile tends
to be noticeable but not dramatic, making an anti-estrogen
(for cardioprotective purposes) perhaps unnecessary. Doses
of 600 mg or less per week have also failed to produce
statistically significant changes in LDL/VLDL cholesterol,
triglycerides, apolipoprotein B/C-III, C-reactive protein, and
insulin sensitivity, all indicating a relatively weak impact on
cardiovascular risk factors.599 When used in moderate doses,
injectable testosterone esters are usually considered to be the
safest of all anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration.
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. Testosterone is the
primary male androgen, and offers strong negative feedback
on endogenous testosterone production. Testosterone-based
drugs will, likewise, have a strong effect on the hypothalamic
regulation of natural steroid hormones. Without the
intervention of testosterone-stimulating substances,
testosterone levels should return to normal within 1-4 months
of drug secession. Note that prolonged hypogonadotrophic
hypogonadism can develop secondary to steroid abuse,

necessitating medical intervention.

Administration (Men):
For the treatment of low androgen levels, the prescribing
guidelines for Testolent recommend administering a dose of
100 mg every 25 days. For physique- or performance enhancing

purposes, this drug is usually injected twice per
week.The total weekly dosage is typically 200-600 mg,
which is sufficient to provide excellent gains in muscle size
and strength. Testosterone drugs are ultimately very
versatile, and can be combined with many other
anabolic/androgenic steroids depending on the desired
effect.
Administration (Women):
The prescribing guidelines for Testolent do not make special
dosing recommendations for women. This drug is not
recommended for women for physique- or performance enhancing

purposes due to its strong androgenic nature,
tendency to produce vitalizing side effects, and slow acting

characteristics (making blood levels difficult to control).
Availability:
Testolent is no longer available as a prescription drug
product.

Testolent (testosterone phenylpropionate) anabolic steroid profile and dosage

akn

Musclechemistry Member

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