via downregulation of insulin and insulin-like growth factor 1 (IGF1) receptors, deleting it (gen) or blocking it increases muscle growth (myofiber number).
View attachment 14256
View attachment 14256
Grb10 protein controls muscle growth
- Thread starter audioloop
- Start date
big in vegas
MuscleChemistry Registered Member
Completely over my head
oswaldosalcedo
New member
a Grb10 protein Blocker
http://www.millipore.com/coa.nsf/a73664f9f981af8c852569b9005b4eee/3f7d570224e19065882579ca007df6c4/$FILE/07-1519_Q1998582.pdf
"Most notably, Grb10 associates with the insulin receptor at phosphotyrosine residues via its C-terminal BPS (between PH
and SH) domain and inhibits the enzymatic activity of the insulin receptor. Grb10 also acts downstream of the insulin receptor pathway to
inhibit activation of AKT-1. In addition, Grb10 suppresses Wnt signalling by binding to the low-density lipoprotein receptor"
.
http://www.millipore.com/coa.nsf/a73664f9f981af8c852569b9005b4eee/3f7d570224e19065882579ca007df6c4/$FILE/07-1519_Q1998582.pdf
"Most notably, Grb10 associates with the insulin receptor at phosphotyrosine residues via its C-terminal BPS (between PH
and SH) domain and inhibits the enzymatic activity of the insulin receptor. Grb10 also acts downstream of the insulin receptor pathway to
inhibit activation of AKT-1. In addition, Grb10 suppresses Wnt signalling by binding to the low-density lipoprotein receptor"
.
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