IMO you will seea really big difference when doseages are the 600-800 range. It depends on what you weigh, what you pay & what can you afford. I see guys firsthand that did the 400mg /wk route and they were disappointed somewhat, Their labmax was good so. I think anyone doing Primo should get this b/c Primo is almost 3x what var is (material cost) and var is often winny or a combo of winny & var.That being said, I think I'm going to give it a shot in the next few weeks. I'll see what comes from 8 weeks at 400mg/wk.