Hello.
First im new there, i read a lot of forum but rarely participate so i will be bref.
I'm french too
i have been doing a couple of recipe. I do a lot of experience on my free time since im in my first years of biochemistry at university.
Now.
My oil recipe is pretty good i use chlorobutanol instead of benzyl alcohol. I use a mini-mixture of eo and benzyl salicylate at really low percentage to only help a little bit to enhance my raw solubility and avoid any pain caused by allergic reaction. I also micronized my raw by precipitation method using solvent and anti-solvent followed by vaccum drying. It help with better assimilation since my crystal are theoricly in amorphous phase so they have a larger wettable area ( aint sure if its the good english term sorry). But it doesnt enhance the solute solubility in my oil. Im using different ratio of castor oil and cottonseed oil to give my finish product a decent viscosity. And i dont have any documentation if a more viscous carrier like castor oil will really absorb more raw than a thinner one. Any evidence on that would be welcome
.
I dont have ton of raw so i try to optimise my experience.
Im preparing to start a winny batch . Inhave set up a recipe like the testosterone suspension pharmaceutical company use but i need help. Since my equipment are farrr away from the pharma one, i have to work harder on my excipient-content ( solvent.cosolvent. ph regulator etc.. ) . For now i will use a saline water, potassium citrate and sodium citrate as my solution buffer. I have read a essay recently promoting the use of l-methionine to help stabilize PH over 12 month and more, where a common buffer solution have a decrease in PH after 3 month and after 6 month the PH is already below 2.5 .I will also use really low amount of polysorbate to avoid deflocculating .i would use between 0.10% to 0.75% of polysorbate 80(preferably between 0.15% and 0.25%). I think i will need a a antioxidant if i try my trenbolone base suspension to avoid it to become dark red. My antimicrobial agent should be benzalkonium chloride since its an cationic surfactant (really useful since it help to reduce repulsive charge between my micronized raw). Now i was thinking about the use of a chelating agent to reduce the metal ion in my suspension. I have some nf lecithin that i could possibly use as wetting agent but i dont know how to calculate the percentage needed with the polysorbate 80 to get an HLB between 7-9 since the ps80 have a high hlb value ( and im not willing to buy polysorbate 20 becaude i need to buy a shit load of it to get a decent purity and i dont think i really meed it) . Isotoniticy can be easily achieve with a low level of dextrose in my suspension. Now that i think i have all my basic ingredient, before starting it i wanna be sure and need some good advice or if i have some modification everything is welcome
i just want to have a heaven-like winny injection because i really hate any tip of pip or muscle pain ! And i fucking got trenbolone base instead of trenbolone acetate so i have to find a way to use it ahahaha ! Please help me ![Smile :) :)](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
First im new there, i read a lot of forum but rarely participate so i will be bref.
I'm french too
i have been doing a couple of recipe. I do a lot of experience on my free time since im in my first years of biochemistry at university.
Now.
My oil recipe is pretty good i use chlorobutanol instead of benzyl alcohol. I use a mini-mixture of eo and benzyl salicylate at really low percentage to only help a little bit to enhance my raw solubility and avoid any pain caused by allergic reaction. I also micronized my raw by precipitation method using solvent and anti-solvent followed by vaccum drying. It help with better assimilation since my crystal are theoricly in amorphous phase so they have a larger wettable area ( aint sure if its the good english term sorry). But it doesnt enhance the solute solubility in my oil. Im using different ratio of castor oil and cottonseed oil to give my finish product a decent viscosity. And i dont have any documentation if a more viscous carrier like castor oil will really absorb more raw than a thinner one. Any evidence on that would be welcome
I dont have ton of raw so i try to optimise my experience.
Im preparing to start a winny batch . Inhave set up a recipe like the testosterone suspension pharmaceutical company use but i need help. Since my equipment are farrr away from the pharma one, i have to work harder on my excipient-content ( solvent.cosolvent. ph regulator etc.. ) . For now i will use a saline water, potassium citrate and sodium citrate as my solution buffer. I have read a essay recently promoting the use of l-methionine to help stabilize PH over 12 month and more, where a common buffer solution have a decrease in PH after 3 month and after 6 month the PH is already below 2.5 .I will also use really low amount of polysorbate to avoid deflocculating .i would use between 0.10% to 0.75% of polysorbate 80(preferably between 0.15% and 0.25%). I think i will need a a antioxidant if i try my trenbolone base suspension to avoid it to become dark red. My antimicrobial agent should be benzalkonium chloride since its an cationic surfactant (really useful since it help to reduce repulsive charge between my micronized raw). Now i was thinking about the use of a chelating agent to reduce the metal ion in my suspension. I have some nf lecithin that i could possibly use as wetting agent but i dont know how to calculate the percentage needed with the polysorbate 80 to get an HLB between 7-9 since the ps80 have a high hlb value ( and im not willing to buy polysorbate 20 becaude i need to buy a shit load of it to get a decent purity and i dont think i really meed it) . Isotoniticy can be easily achieve with a low level of dextrose in my suspension. Now that i think i have all my basic ingredient, before starting it i wanna be sure and need some good advice or if i have some modification everything is welcome