MyoGro
- Thread starter getripped
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einstein1905
New member
getripped said:
I'm not sure where you read you were to inject sub Q, but you'd get much better results going IM. Read the other two most recent posts about the "myostatin inhibitor". The manufacturer is taking a long time in getting back to me on some questions I had for them. Like I said before, RNA is very susceptible to degradation. To get the best results, you'll need to get it to its target the quickest most direct way possible....an IM injection. the results will have to be site-specific, as the RNA isn't going to be migrating anywhere before degradation. Also, to be effective, it must get into the cytoplasm to associate (form double stranded RNA) with the myostatin mRNA, thus preventing protein expression of myostatin. Some RNA will get into the cytoplasm after an inject, but there is no real driving force getting the RNA into the cells themselves. however, once in....should do amazing things. As I said before, I'll be trying some soon.
proud13
New member
I will soon have myogro and another proven myostatin inhibitor en route and will start testing them soon. The other one I am testing is FSH which can increase follistatin which in turn also binds to myostatin.
I have been trying to locate a source of MGF for some time now but no luck as of yet. MGF is mechano growth factor and is similar to IGF but it acts only in a localized manner on damaged muscle tissue (i.e.-weight resistance training).
I have IL-15 right now but I am waiting to get my HGH to stack it with or I may order IGF-1 R3 which, from what I've read in studies and hearsay would be pretty amazing results.
Des IGF-1 is 1000% times stronger than IGF-1 R3 but the price is about $2000-3000 per mg for it so at this time it is only for the NOC or Olympia contenders with large supplement funds and supplies.
I have been trying to locate a source of MGF for some time now but no luck as of yet. MGF is mechano growth factor and is similar to IGF but it acts only in a localized manner on damaged muscle tissue (i.e.-weight resistance training).
I have IL-15 right now but I am waiting to get my HGH to stack it with or I may order IGF-1 R3 which, from what I've read in studies and hearsay would be pretty amazing results.
Des IGF-1 is 1000% times stronger than IGF-1 R3 but the price is about $2000-3000 per mg for it so at this time it is only for the NOC or Olympia contenders with large supplement funds and supplies.
proud13
New member
You asked for it KidRock....
IL-15 and skeletal muscle....
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7628408&dopt=Abstract
IL-15 and skeletal muscle....
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7628408&dopt=Abstract
proud13
New member
Myostatin knock out mice and pictures of them....along with other info on myostatin...
http://www.mesomorphosis.com/articles/volk/myostatin.htm
http://www.mesomorphosis.com/articles/volk/myostatin.htm
proud13
New member
Myostatin again but about the only part you really need to read is the last sentence or two with the conclusion.
http://www.pnas.org/cgi/content/abstract/95/25/14938
http://www.pnas.org/cgi/content/abstract/95/25/14938
proud13
New member
proud13
New member
I'm not done yet...this is des (3) IGF and the last sentence is very important!!!!!! It says even in nitrogen deficit des IGF shows remarkable ability to keep skeletal muscle which is normally unheard of and think about if you're on gear and eating like a chapm...your gains would at least double....the only thing is des IGF is very, very expensive.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1999680&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1999680&dopt=Abstract
proud13
New member
THE HOLY GRAIL OF THEM ALL.....MGF...this stuff has been shown to increase muscle hypertrophy and muscle mass by 25% over 4 months. Can you imagine that???? 18 inch arms would/could be 22 inches in less than a year.....
Okay I'll stop now I'm getting wet at the thought.
http://www.physoc.org/publications/pn/issuepdf/53/22.pdf
Okay I'll stop now I'm getting wet at the thought.
http://www.physoc.org/publications/pn/issuepdf/53/22.pdf
proud13
New member
Novel Tissue Repair/Growth Factor for the Treatment of Muscular and Nervous Disorders
Background
In muscular and neuronal tissue there is no cell replacement once embryological differentiation is complete at or near birth. Therefore there has to be an effective local cellular mechanism to repair the physical and free radical induced tissue damage that occurs throughout life. If this damage is not repaired quickly the cells die rapidly creating a permanent deficit, as occurs during old age when local tissue repair mechanisms start to break down.
Technology Summary
The cDNA of three human insulin-like growth factor I (IGF-I) splice variants have been cloned in human muscle by researchers at the Royal Free and University College Medical School, University College London. The mRNA of one of these IGF-I splice variants was found to be detectable only in exercised and/or damaged (e.g. stretched or electrically stimulated) muscle. Its expression was found to be related to the level of muscular activity and it was subsequently named 'Mechano Growth Factor' (MGF). The biological activity of MGF has been tested both in vivo by intramuscular injection into mice of the cDNA contained in a suitable muscle expression vector, and in vitro by injection into cultured myocytes. Intramuscular injection of MGF resulted in a 20% increase in muscle wet weight and a 25% increase in mean muscle fibre size after only two weeks, with subcutaneous administration resulting in no significant increase in wet weight of underlying muscle, thus suggesting a localised action.
Development Status
MGF has been found to be expressed in mouse, rabbit and human muscle, with sequence studies showing MGF to have a number of domains, some of which have similar sequences to the liver systemic type of IGF-I, but one which activates muscle stem cells and another that recognises a specific binding protein. The binding protein has been found to be present in abundance in both skeletal and cardiac muscle, where it stabilises MGF and localises its action, thus reducing the risk of potential side-effects on non-target cells/tissue. MGF has not only been found to be expressed in muscle but also in other types of damaged tissue where it upregulates protein synthesis and induces the stem cells required for tissue regeneration. A number of different therapeutic applications of MGF are currently being developed together with academic and commercial collaborators.
Intellectual Property
Several patent applications have now been filed covering the use of MGF for the treatment of muscular disorders, liver dysfunction, neurological disorders and peripheral nerve damage together with related methodologies. A patent has already been granted in the USA covering pharmaceutical compositions containing MGF, with applications currently pending in Europe and Japan. UCL BioMedica Plc is now looking to licence some of these technologies and to develop applications and products based on their use together with appropriate commercial partners.
Background
In muscular and neuronal tissue there is no cell replacement once embryological differentiation is complete at or near birth. Therefore there has to be an effective local cellular mechanism to repair the physical and free radical induced tissue damage that occurs throughout life. If this damage is not repaired quickly the cells die rapidly creating a permanent deficit, as occurs during old age when local tissue repair mechanisms start to break down.
Technology Summary
The cDNA of three human insulin-like growth factor I (IGF-I) splice variants have been cloned in human muscle by researchers at the Royal Free and University College Medical School, University College London. The mRNA of one of these IGF-I splice variants was found to be detectable only in exercised and/or damaged (e.g. stretched or electrically stimulated) muscle. Its expression was found to be related to the level of muscular activity and it was subsequently named 'Mechano Growth Factor' (MGF). The biological activity of MGF has been tested both in vivo by intramuscular injection into mice of the cDNA contained in a suitable muscle expression vector, and in vitro by injection into cultured myocytes. Intramuscular injection of MGF resulted in a 20% increase in muscle wet weight and a 25% increase in mean muscle fibre size after only two weeks, with subcutaneous administration resulting in no significant increase in wet weight of underlying muscle, thus suggesting a localised action.
Development Status
MGF has been found to be expressed in mouse, rabbit and human muscle, with sequence studies showing MGF to have a number of domains, some of which have similar sequences to the liver systemic type of IGF-I, but one which activates muscle stem cells and another that recognises a specific binding protein. The binding protein has been found to be present in abundance in both skeletal and cardiac muscle, where it stabilises MGF and localises its action, thus reducing the risk of potential side-effects on non-target cells/tissue. MGF has not only been found to be expressed in muscle but also in other types of damaged tissue where it upregulates protein synthesis and induces the stem cells required for tissue regeneration. A number of different therapeutic applications of MGF are currently being developed together with academic and commercial collaborators.
Intellectual Property
Several patent applications have now been filed covering the use of MGF for the treatment of muscular disorders, liver dysfunction, neurological disorders and peripheral nerve damage together with related methodologies. A patent has already been granted in the USA covering pharmaceutical compositions containing MGF, with applications currently pending in Europe and Japan. UCL BioMedica Plc is now looking to licence some of these technologies and to develop applications and products based on their use together with appropriate commercial partners.
Juice Freak
New member
WoW............
That's freakin awesome......
That's freakin awesome......
supersport
New member
proud13 said:
I am a little concerned about the validity of this study. I am not going to argue whether or not Myostatin increases muscular hypertrophy because I am not familiar enough with it.
However I am very familiar with the HIV/AIDS model, and I must say that the reason for my skepticism is that from what I gather this study was done on HIV-Positive men suffering from wasting syndrome.
A large body in the scientific community-The Group for the Reappraisal of Aids-a membership of over 1500 scientists(including no less than 3 Nobel Prize winners) all say that HIV does not cause Aids. Most, if not all, agree with Peter Duesberg, PhD, Microbiologist U. Cal-Berkeley (he was California's Scientist of the year 1971, discovered the first cancer gene in 1970, and in fact "mapped " retroviruses{of which HIV is a member of} and is considered a world renouned expert in retroviral science) that HIV is a latent passenger virus that exudes no cytocidal abilities whatsoever. In short, HIV does not cause aids, much less wasting syndrome. Actually, it causes nothing.
There is not one single document that has been published that shows or proves how HIV causes AIDS. Not a single one. What has been proven is that the uninformed public is willing to swallow a theory based on correlation and misrepresentation-however that is a cannonball that the scientific community is not swallowing-no matter how well lubricated. It should be noted that correlation is not proof of causation.
The original cell cultures sent to Dr. Robert Gallo of the National Cancer Institute, scientist and self proclaimed discoverer of HIV ( A lie-Dr. Montegnier of the Pastuer institute in France discovered HIV-and sent Gallo cultures on 2 different occasions-the beginning of the HIV-AIDS hoax) only showed 41% of the "AIDS patient" cultures had HIV virus-and not even 100% were anti-body positive. In scientific circles, this is a bad joke.
Even someone being HIV anti-body positive is questionable. There are over 64 known triggers of false positive tests-including flu virus and hepatitis vaccinations. The big problem is the HIV test is non specific-meaning particles of another virus or protien altogether will trigger a false positive antibody test.
Another huge hole in this hypothesis is that the supposed HIV virus (reading between the lines yet? lol) is that the virus has never been properly isolated-this is why there are so many false positives. There is no gold standard to back up an HIV antibody test. One lab can tell you a subject is positive, and another lab with the same blood from the same blood draw will come back negative.
The real cause of AIDS is drugs-most notably cocaine and amyl nitates-"poppers". Other players are numerous antibiotics, malnutrition, anal sex (sperm contact with anal linings supposedly has pronounced immune depression-still investigating this), extasy etc. All of these products have severe immuno depressive effects.
But perhaps the most notable is AZT-the very drug indicated for antiviral therapy actually causes aids-what a paradox.
IMO this study should have been performed on healthy subjects-not HIV patients suffering from wasting syndrome that is highly likely caused by drug consumption (if they even have HIV is questionable.
Myostatin may serve well for BB'ing and other circles, but IMO this study is severly flawed. Who knows what drugs (rec or pharmaceutical) these subjects were taking. I saw nothing mentioned of a blood test or urinalysis.
--SS
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