It took about 8 weeks for me I think before I had any real tissue growth.... I had had painful puffy nips in previous cycles but they always went away w/ no fibrous tissue remaining. During the cycle I explained in my above post, the one that gave me gyno, I was in extreme pain for at least 8 weeks every single day. So in my case it took a long time before any real tissue grew. So when I hear my friends freaking out cuz there nips hurt I tell them not to worry.... I think any real tissue growth takes some serious time to grow.... but remember, everyone is different so you might get some hard tissue growth faster than me... I am just saying for me the hard tissue takes months to grow.