In the evening I will only use humalog as its fast hitting and out of your body in 2 hrs. But, rememeber everyone is different. I might be able to take humalog at 10 at night, and be totally fine. But the next guy will go into a diabetic coma. So be careful, I believe its before 7-8pm and you dont go to bed within 4-5 hours 11pm- 12am, you will be alright. As long as you eat the right amount of carbs. (which for me is around 8-10 grams for every 1 iu of insulin. So if I take 5 iu's I would take a min of 40 carbs or 50 grams of carbs) . Again play around with it, and see what you can handle, but be very careful as you might think its out of you, but within a hour your sweating like crazy.